Compositions and methods for inhibiting arginase activity
The disclosure relates to a novel class of compounds that exhibit activity inhibitory activity toward arginase, and pharmaceutical compositions comprising the compounds of the disclosure. Also provided herein are methods of treating cancer with the arginase inhibitors of the disclosure.
1. A compound having a structure of formula (I*):
or a pharmaceutically acceptable salt thereof;
wherein:
R 1 is methyl; and
R 4 is H or (C 1 -C 6 )alkyl.
2. The compound of claim 1 , having a structure of the following formula:
3. The compound of claim 1 , having a structure of the following formula:
4. The compound of claim 1 , wherein R 4 is (C 1 -C 6 )alkyl.
5. The compound of claim 4 , wherein R 4 is methyl, ethyl, propyl, or isopropyl.
6. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
7. A compound having the following structure:
or a pharmaceutically acceptable salt thereof.
8. A solid pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
9. The compound of claim 6 , having the following structure:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 6 , having the following structure:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 7 , having the following structure:
or a pharmaceutically acceptable salt thereof.
12. The compound of claim 7 , having the following structure:
or a pharmaceutically acceptable salt thereof.
13. The compound of claim 1 , wherein R 4 is H.
14. The compound of claim 2 , wherein R 4 is H.
15. The compound of claim 2 , wherein R 4 is (C 1 -C 6 )alkyl.
16. The compound of claim 15 , wherein R 4 is methyl, ethyl, propyl, or isopropyl.
17. The compound of claim 3 , wherein R 4 is H.
18. The compound of claim 3 , wherein R 4 is (C 1 -C 6 )alkyl.
19. The compound of claim 18 , wherein R 4 is methyl, ethyl, propyl, or isopropyl.
20. A solid pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
21. A solid pharmaceutical composition comprising a compound of claim 4 and a pharmaceutically acceptable carrier.
22. A solid pharmaceutical composition comprising a compound of claim 3 and a pharmaceutically acceptable carrier.
23. A solid pharmaceutical composition comprising a compound of claim 7 and a pharmaceutically acceptable carrier.
24. A solid pharmaceutical composition comprising a compound of claim 10 and a pharmaceutically acceptable carrier.
25. A solid pharmaceutical composition comprising a compound of claim 12 and a pharmaceutically acceptable carrier.
26. A solid pharmaceutical composition comprising a compound of claim 18 and a pharmaceutically acceptable carrier.