Screening method, a kit, a method of treatment and a compound for use in a method of treatement
A method of screening for a candidate compound for the treatment of a condition involving dysregulation of metabolism in a mammal, said method comprising bringing a compound into contact with at least one population of cells, comprising cells that express mTOR and Akt and that are capable of activating mTORC2 and Akt; determining mTORC2 activity and Akt activity in cells brought into contact with the compound, and identifying the candidate compound based on the determined mTORC2 activity and Akt activity. A kit for use in such a method of. A compound for use in a method of treatment of a condition involving dysregulation of metabolism in a mammal, and a method of treatment of such a condition.
1. A method of treatment or prevention of a condition involving a dysregulation of glucose homeostasis or glucose uptake in a human, comprising administering, to a human in need of such treatment, a therapeutically effective amount of clenbuterol.
2. The method of claim 1 , wherein the condition is diabetes.