Particulate formulations for improving feed conversion rate in a subject
Disclosed are compositions, kits, and methods for improving feed conversion rate in an animal in need thereof. The methods typically comprise administering orally to the animal a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polylactide (PLA) and having an effective average diameter of 0.5-5 μm. In the methods, the animal is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the animal in comparison to an animal that is not administered the composition.
1. A method for improving feed conversion rate in an animal in need thereof, the method comprising administering orally to the animal a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polylactide (PLA) and having an effective average diameter of 0.5-5 μm, wherein the animal is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the animal in comparison to an animal that is not administered the composition.
2. The method of claim 1 , wherein the biodegradable particles have an effective average diameter of 0.5-3 μm.
3. The method of claim 1 , comprising administering the biodegradable particles to the subject at dose between (BW/20) 3/4 μg and 100×((BW/20) 3/4 ) μg, wherein BW is the body weight of the subject in grams.
4. The method of claim 1 , wherein the animal is a fowl.
5. The method of claim 4 , wherein the fowl is a chicken.
6. The method of claim 5 , comprising administering the biodegradable particles to the chicken at dose between (BW/20) 3/4 μg and 100×((BW/20) 3/4 ) μg, wherein BW is the body weight of the chicken in grams.
7. The method of claim 5 , wherein the chicken is administered a dose of 26.7-270 μg of the biodegradable particles.
8. The method of claim 1 , wherein the polymer or the co-polymer further comprises poly(lactic-co-glycolic acid) (PLGA).
9. The method of claim 1 , wherein the biodegradable particles are prepared via performing spray-drying of a mixture consisting of (i) the polymer or co-polymer and (ii) a surfactant.
10. The method of claim 9 , wherein the surfactant is a co-polymer adjuvant.
11. A method for improving feed conversion rate in a chicken hatchling in need thereof, the method comprising administering orally to the chicken hatchling a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polylactide (PLA) and having an effective average diameter of 0.5-5 μm, wherein the chicken hatchling is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the chicken hatchling in comparison to a chicken hatchling that is not administered the composition.
12. The method of claim 11 , wherein the polymer or the co-polymer further comprises poly(lactic-co-glycolic acid) (PLGA).
13. The method of claim 11 , comprising administering the biodegradable particles to the chicken hatchling at dose between (BW/20) 3/4 μg and 100×((BW/20) 3/4 ) μg, wherein BW is the body weight of the chicken hatchling in grams.
14. The method of claim 11 , wherein the chicken hatchling is administered a dose of 26.7-270 μg of the biodegradable particles.
15. The method of claim 11 , wherein the biodegradable particles are prepared via performing spray-drying of a mixture consisting of (i) the polymer or co-polymer and (ii) a surfactant.
16. The method of claim 15 , wherein the surfactant is a co-polymer adjuvant.
17. A method for improving feed conversion rate in a swine in need thereof, the method comprising administering orally to the swine a composition comprising biodegradable particles, the biodegradable particles comprising a polymer or a co-polymer comprising polylactide (PLA) and having an effective average diameter of 0.5-5 μm, wherein the swine is administered a dose of the biodegradable particles that is effective for improving feed conversion rate in the swine in comparison to a swine that is not administered the composition.
18. The method of claim 17 , comprising administering the biodegradable particles to the swine at dose between (BW/20) 3/4 μg and 100×((BW/20) 3/4 )μg, wherein BW is the body weight of the swine in grams.
19. The method of claim 17 , wherein the biodegradable particles are prepared via performing spray-drying of a mixture consisting of (i) the polymer or co-polymer and (ii) a surfactant.
20. The method of claim 19 , wherein the surfactant is a co-polymer adjuvant.