IP Library › Granted Patent US 10,301,323
Granted Patent B2
US 10,301,323 · App. 16/046,304 · Granted May 28, 2019

Histone deacetylase inhibitors

Inventors: Vincent Jacques (Somerville, MA); James R. Rusche (Framingham, MA); Norton P. Peet (North Andover, MA); Jasbir Singh (Naperville, IL)
Assignee: BIOMARIN PHARMACEUTICAL INC.
C07D513/04C07D205/06C07D211/70C07D211/78C07D231/12C07D261/08C07D263/32C07D277/30C07D277/34C07D305/10C07D401/06C07D403/06C07D403/10C07D451/02C07D471/04C07D471/08
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Quick Facts
Patent No.
US 10,301,323
App. No.
16/046,304
Granted
May 28, 2019
Kind
B2
Abstract

This invention relates to generally inhibiting histone deacetylase (“HDAC”) enzymes (e.g., HDAC1, HDAC2, and HDAC3).

Claims (15)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. The compound or salt of claim 1 , having a structure:

3. The compound or salt of claim 1 , having a structure:

4. The compound or salt of claim 1 , having a structure:

5. The compound or salt of claim 1 , having a structure:

6. The compound or salt of claim 1 , having a structure:

7. The compound or salt of claim 1 , having a structure:

8. The compound or salt of claim 1 , having a structure:

9. The compound or salt of claim 1 , having a structure:

10. The compound or salt of claim 1 , having a structure:

11. The compound or salt of claim 1 , having a structure:

12. The compound or salt of claim 1 , having a structure:

13. The compound or salt of claim 1 , having a structure:

14. The compound or salt of claim 1 , having a structure:

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 14, 2018
From: JACQUES, VINCENT; RUSCHE, JAMES R.; PEET, NORTON P.; SINGH, JASBIR
To: REPLIGEN CORPORATION
Reel/Frame 046633/0075 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 14, 2018
From: REPLIGEN CORPORATION
To: BIOMARIN PHARMACEUTICAL INC.
Reel/Frame 046633/0164 →
Continuity (7)
Continuation 15860741 · Jan 3, 2018
Continuation 15337354 · Oct 28, 2016
Continuation 14598583 · Jan 16, 2015
Continuation 13843261 · Mar 15, 2013
Continuation In Part PCTUS2012026874 · Feb 28, 2012
Provisional Application 61447416 · Feb 28, 2011
Related Publication 20180327423A1 · Nov 15, 2018