Resuscitation composition and methods of making and using
A resuscitation composition is described herein, as are methods of making and using such a composition.
1. A resuscitation composition comprising about 40 mM to 45 mM melatonin, about 3.8 M to about 4.2 M beta-hydroxybutyrate (BHB) or a pharmaceutically acceptable salt thereof in a solution of about 8% to about 12% hydroxypropyl-beta-cyclodextrin (HPbCD), about 4% to about 6% polyvinylpyrrolidone (PVP) and about 4% to about 6% polyethylene glycol (PEG).
2. The composition of claim 1 , comprising about 43 mM melatonin.
3. The composition of claim 1 , comprising about 4.0 M BHB.
4. The composition of claim 1 , comprising about 10% HPbCD, 5% PVP, and 5% PEG.
5. The composition of claim 1 , wherein the pharmaceutically acceptable salt is Na-BHB.
6. The composition of claim 1 , wherein the composition is lyophilized.
7. The composition of claim 1 , wherein the composition further comprises a stabilizer.
8. An article of manufacture comprising the composition of claim 1 .
9. A method for treating an individual who is experiencing or has experienced a major hemorrhagic event, comprising administering the composition of claim 1 to the individual.
10. The method of claim 9 , wherein the composition is administered to the individual before the individual has lost about 10% blood volume.
11. The method of claim 9 , wherein the composition is administered to the individual before the individual has lost about 20% blood volume.
12. The method of claim 9 , wherein the composition is administered to the individual before the individual has lost about 30%.blood volume.
13. The method of claim 9 , wherein the blood loss in the individual results in a systolic blood pressure of about 70 mm Hg or less.
14. The method of claim 9 , wherein the composition is administered at a volume of about 0.1 to about 5 milliliters (mls) per kilogram (kg) of weight of the individual.
15. The method of claim 9 , wherein the composition is administered at a volume of about 0.1 to about 5 mLs per kg of weight of the individual per hour.
16. The method of claim 9 , wherein the composition is administered intravenously or intraosseously.
17. The method of claim 9 , further comprising transfusing the individual with blood or plasma.