Device and method for providing a synergistic combination of phototherapy and a non-light energy modality to the brain
Systems and methods that could reduce the potential for side effects while delivering a reduced amount of light energy and non-light energy to a patient while providing a desired therapeutic effect that might otherwise only be achievable with a higher dose of either the light energy or non-light energy administered alone are disclosed. In certain embodiments, disclosed is a system and method for treating a patient, by administering a combination of light therapy from a light energy source in addition to one, two, or more other non-light energy modalities to a target region of a patient for a synergistic therapeutic effect.
1. A method for treating a patient's brain, comprising:
administering, to a target tissue of the patient's brain, an amount of light energy; and
administering, to the target tissue of the patient's brain, an amount of non-light energy, wherein the amount of non-light energy is a subtherapeutic amount of energy,
wherein the administrations of the amount of light energy and the amount of non-light energy occur within 24 hours of each other,
wherein the administrations of the amount of light energy and the amount of non-light energy produce a combined treatment effect to the patient that is greater than a sum of: (i) a treatment effect produced by administering the amount of light energy alone plus (ii) a treatment effect produced by administering the amount of non-light energy alone, and
wherein the time-averaged irradiance of the amount of light energy at the target tissue of the patient's brain is less than 100 mW/cm 2 .
2. The method of claim 1 , wherein the amount of light energy and the amount of non-light energy are administered concurrently.
3. The method of claim 1 , wherein the non-light energy is magnetic energy.
4. The method of claim 3 , wherein the administering the amount of non-light energy comprises trans-cranial magnetic stimulation.
5. The method of claim 1 , wherein the light energy has a wavelength between 630 nanometers to 1064 nanometers.
6. The method of claim 1 , wherein the light energy has a wavelength between 730 nanometers to 840 nanometers.
7. The method of claim 1 , wherein the light energy has a wavelength between 730 nanometers and 750 nanometers.
8. The method of claim 1 , wherein the amount of light energy and the amount of non-light energy are delivered in alternating pulses.
9. A method for treating a patient's brain, comprising:
administering, to a target tissue of the patient's brain, an amount of light energy; and
administering, to the target tissue of the patient's brain, an amount of non-light energy,
wherein the amount of non-light energy is a subtherapeutic amount of energy,
wherein the administration of the amount of light energy and the amount of non-light energy occur within 24 hours of each other, and
wherein the administrations of the amount of light energy and the amount of non-light energy produce a combined treatment effect to the patient that is greater than a sum of: (i) a treatment effect produced by administering the amount of light energy alone plus (ii) a treatment effect produced by administering the amount of non-light energy alone.
10. The method of claim 9 , wherein the combined treatment effect comprises improvement of neurologic function.
11. The method of claim 9 , wherein the amount of light energy and the amount of non-light energy are administered concurrently.
12. The method of claim 9 , wherein the non-light energy is magnetic energy.
13. The method of claim 9 , wherein the light energy has a wavelength between 630 nanometers to 1064 nanometers.
14. The method of claim 9 , wherein the light energy has a wavelength between 730 nanometers to 840 nanometers.
15. The method of claim 9 , wherein the light energy has a wavelength between 730 nanometers and 750 nanometers.
16. The method of claim 9 , wherein the amount of light energy and the amount of non-light energy are delivered in alternating pulses.