Tandem facial amphiphiles

1. A compound of Formula I:

wherein

L is (C 5 -C 8 )cycloalkyl; phenyl optionally substituted by 1-4 (C 1 -C 4 )alkyl; —C(R x ) 2 —; or —CH 2 —C(R x ) 2 —CH 2 —; where each R x is independently OH, or —CH 2 O—Sac;

each X is independently O, S, NH, triazole; or a direct bond;

each m is 0 or 1;

each R 1 is independently H or (C 1 -C 20 )alkyl; and

each Amph is independently a moiety of Formula A:

wherein

Y is CH 2 or a direct bond;

each R 2 , R 3 , and R 4 is independently H, OH, or O-Sac; and

each Sac is independently a monosaccharide, disaccharide, or trisaccharide;

wherein the compound has at least 4 Sac groups.

2. The compound of claim 1 wherein each R 1 is (C 1 -C 20 )alkyl.

3. The compound of claim 1 wherein Y is a direct bond.

4. The compound of claim 1 wherein at least two of R 2 , R 3 and R 3 are O-Sac and each Sac is a disaccharide.

5. The compound claim 1 wherein the compound is a compound of Formula III:

6. A compound of Formula XII:

wherein each R 2 is independently an oxygen-linked monosaccharide, disaccharide, or trisaccharide and each R 3 and R 4 is independently H, OH, or an oxygen-linked monosaccharide, disaccharide, or trisaccharide; and

wherein the compound has at least four oxygen-linked monosaccharide, disaccharide, or trisaccharide groups.

7. The compound claim 6 wherein the compound is:

8. A compound of Formula

wherein

each R 2 , R 3 , and R 4 is independently H, OH, or O-Sac; and

each Sac is independently a monosaccharide, disaccharide, or trisaccharide; and

wherein the compound has at least four Sac groups.

9. The compound claim 8 wherein the compound is:

10. A compound of Formula XIV:

wherein each X is independently O, S, NH, triazole; or a direct bond; and

each R 2 is independently an oxygen-linked monosaccharide, disaccharide, or trisaccharide and each R 3 and R 4 is independently H, OH, or an oxygen-linked monosaccharide, disaccharide, or trisaccharide; and

wherein the compound has at least four oxygen-linked monosaccharide, disaccharide, or trisaccharide groups.

11. The compound claim 10 wherein the compound is:

12. A compound of Formula I:

Amph-X-L-X-Amph  (I)

wherein

L is (C 5 -C 8 )cycloalkyl; phenyl optionally substituted by 1-4 (C 1 -C 4 )alkyl; —(CH 2 ) n — where n is 1-10; —C(R x ) 2 —; or —CH 2 —C(R x ) 2 —CH 2 —; where each R x is independently H, OH, or —CH 2 O—Sac;

each X is independently O, S, NH, CH 2 , triazole; or a direct bond; and

each Amph is independently a moiety of Formula A:

wherein

Y is CH 2 or a direct bond;

each R 2 , R 3 , and R 4 is independently H, OH, or O-Sac; and

each Sac is independently a monosaccharide, disaccharide, or trisaccharide;

wherein the compound has at least 4 Sac groups.

13. The compound claim 12 wherein the compound is a compound of Formula VII:

wherein each X is independently O, S, NH, CH 2 , or triazole; and n is −1, 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

14. The compound claim 13 wherein the compound is a compound of Formula VIII:

wherein each X is S, O, CH 2 , or

15. The compound of claim 1 wherein a plurality of the compounds form a micelle in water comprising about 6 to about 15 molecules of the compound.

16. A compound of Formula I:

where L is (C 5 -C 8 )cycloalkyl; a phenyl diradical optionally substituted by 1, 2, 3, or 4 (C 1 -C 4 )alkyl groups; —C(R x ) 2 —; or —CH 2 —C(R x ) 2 —CH 2 —; where each R x is independently OH, or —CH 2 O-Sac;

each X is independently O, S, NH, CH 2 , triazole, or a direct bond;

each m is 0 or 1;

each R 1 is independently (C 5 -C 20 )alkyl; and

each Amph is independently a moiety of Formula A:

wherein

Y is CH 2 or a direct bond;

each R 2 , R 3 , and R 4 is independently H, OH, or O-Sac; and

each Sac is independently an oxygen-linked monosaccharide, disaccharide, or trisaccharide where the compound of Formula I has at least 4 Sac groups.