Prebiotic oral care methods using a saccharide
The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myoinositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.
1. A method of cleaning tooth enamel comprising contacting the dental surfaces in a subject with a toothpaste composition without intentional ingestion of the toothpaste composition, wherein the toothpaste composition comprises all of the following ingredients:
N-acetyl-D-mannosamine in an amount of 0.1% to 5% by weight of the composition;
water;
an abrasive for removing debris and surface stains;
a surfactant;
a humectant;
a thickener;
a flavoring;
wherein the N-acetyl-D-mannosamine promotes the growth, metabolic activity, or colonization of a bacteria having beneficial effects on oral health selected from the group consisting of Streptococcus mitis, Streptococcus sanguinis, Veillonella parvula, Streptococcus gordonii , and Actinomyces naeslundii , relative to growth, metabolic activity or colonization of pathogenic oral bacteria.
2. The method of claim 1 , wherein the subject has one or more of gingivitis, periodontitis, peri-implantitis, peri-implant mucositis, necrotizing gingivitis, necrotizing periodontitis and caries.
3. The method of claim 1 , wherein the cleaning of tooth enamel negatively affects the growth of pathogenic bacterial species selected from the group consisting of: Porphyromonas gingivalis, Tannerella forsythia , and combinations thereof.
4. The method of claim 1 , wherein the toothpaste composition is applied by brushing.
5. The method of claim 1 , wherein the toothpaste composition further comprises at least one member selected from the group consisting of a vitamin, an anti-caries agent, a dental surface whitening agent, an enzyme, an antimicrobial agent, and a preservative.
6. The method of claim 1 , wherein the N-acetyl-D-mannosamine is not derived from a plant extract.
7. The method of claim 1 , wherein the abrasive is a precipitated silica sized from about 0.1 μm to about 30 μm.
8. The method of claim 1 , wherein the surfactant is selected from the group consisting of a cationic surfactant, an anionic surfactant, a zwitterionic surfactant, and a non-ionic surfactant.
9. The method of claim 1 , wherein the humectant is selected from the group consisting of glycerin, sorbitol, xylitol, butylene glycol, polyethylene glycol, propylene glycol, trimethyl glycine, and mixtures thereof.
10. The method of claim 1 , wherein the thickener is selected from the group consisting of a carboxyvinyl polymer, carrageenan gum, hydroxyethyl cellulose, veegum, clay, sodium carboxymethylcellulose, sodium carboxymethyl hydroxyethyl cellulose, gum karaya, xanthan gum, gum Arabic, gum tragacanth, colloidal magnesium aluminum silicate, finely divided silica, cross-linked poly(vinyl)pyrrolidone, stearic acid, palmitic acid, stearyl alcohol, and mixtures thereof.
11. The method of claim 1 , wherein the toothpaste composition further comprises a buffer which adjusts the pH of the composition to a range of about 4.0 to about 6.0.
12. The method of claim 1 , wherein the flavoring comprises a mixture of peppermint oil and spearmint oil.
13. The method of claim 5 , wherein the anti-caries agent is a fluoride source.
14. The method of claim 5 , wherein the dental surface whitening agent is selected from the group consisting of urea peroxide, calcium peroxyphosphate, sodium perborate, sodium carbonate peroxide, sodium peroxyphosphate, potassium persulfate, and a peroxide-polyvinyl pyrrolidone polymer complex.