Composition, cell structure, pancreatic islet transplantation kit, pancreatic islet cell transplantation treatment agent and hypoglycemic agent, composition containing pancreatic islet, kit containing pancreatic islet, and pancreatic islet transplantation treatment agent and hypoglycemic agent
An object is to provide a composition containing a pancreatic islet, a cell structure containing a pancreatic islet or a pancreatic islet cell, a pancreatic islet transplantation kit, a pancreatic islet transplantation treatment agent, and a hypoglycemic agent which improve at least one of glucose sensitivity or blood sugar level-reducing performance after transplantation, and to provide a composition containing a pancreatic islet, a kit containing a pancreatic islet, a pancreatic islet cell transplantation treatment agent, and a hypoglycemic agent which can improve glucose sensitivity. A composition including (A): a cell structure containing a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the above-described macromolecular blocks are arranged in gaps between a plurality of the above-described cells; and (B): a pancreatic islet, and a composition containing a pancreatic islet; and a spheroid formed of at least one type of stem cell are provided.
1. A composition comprising:
(A): a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the macromolecular blocks are arranged in gaps between a plurality of the cells; and
(B): a pancreatic islet,
wherein said biocompatible macromolecular block is a polypeptide, and said at least one kind of cell comprises a mesenchymal stem cell, and said pancreatic islet is an aggregate of a α cell, a β cell, a δ cell, a ε cell and a PP cell.
2. The composition according to claim 1 ,
wherein the thickness or the diameter of the cell structure is 100 μm to 3 cm.
3. The composition according to claim 1 ,
wherein the biocompatible macromolecular block is formed of a recombinant peptide.
4. A cell structure comprising:
a biocompatible macromolecular block;
at least one kind of cell; and
a pancreatic islet,
wherein a plurality of the macromolecular blocks are arranged in gaps between a plurality of the cells,
wherein said biocompatible macromolecular block is a polypeptide, said at least one kind of cell comprises a mesenchymal stem cell, and said pancreatic islet is an aggregate of a α cell, a β cell, a δ cell, ε cell and a PP cell.
5. The cell structure according to claim 4 ,
wherein SI, which is an amount of insulin during culture in 20 mM glucose medium/amount of insulin during culture in 3 mM glucose medium, is greater than or equal to 3.0.
6. The cell structure according to claim 4 ,
wherein the biocompatible macromolecular block is a recombinant peptide.
7. A pancreatic islet transplantation kit, comprising:
A): a cell structure which contains a biocompatible macromolecular block and at least one kind of cell and in which a plurality of the macromolecular blocks are arranged in gaps between a plurality of the cells; and
(B): a pancreatic islet,
wherein said biocompatible macromolecular block is a polypeptide, and said at least one kind of cell comprises a mesenchymal stem cell, and said pancreatic islet is an aggregate of a α cell, a β cell, a δ cell, a ε cell and a PP cell.
8. The pancreatic islet transplantation kit according to claim 7 ,
wherein the thickness or the diameter of the cell structure is 100 μm to 3 cm.
9. The pancreatic islet transplantation kit according to claim 7 ,
wherein the biocompatible macromolecular block is formed of a recombinant peptide.