Granted Patent
B2
US 10,343,993 · App. 15/555,092 · Granted Jul 9, 2019
Processes and intermediates for the preparation of Pimavanserin
Inventors:
Tomislav Biljan (Krizevci, HR); Jasna Dogan (Zagreb, HR); Leonid Metsger (Levahim, IL); Sara Morasi Pipercic (Novi Marof, HR); Marina Ratkaj (Zagreb, HR); Maja Matanovic Skugor (Zagreb, HR); Yi Wang (Chester Springs, PA)
Assignee:
Pliva Hrvatska d.o.o.
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Abstract
The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
Claims (6)
1. A compound of formula (XVII), (Z), or (XIX):
wherein:
R 1 is a 2-methylpropan-oxy (“isobutoxy”) group or a group that can be converted into an isobutoxy group.
2. The compound of formula (XVII) of claim 1 , that is:
3. The compound of formula (Z) of claim 1 , that is:
4. The compound of formula (XIX) of claim 1 , wherein R 1 is 2-methylpropan-oxy.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 11, 2025
From: PLIVA HRVATSKA D.O.O.
To: TAPI CROATIA INDUSTRIES LTD
Reel/Frame 071080/0428 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 6, 2017
From: METSGER, LEONID
To: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
Reel/Frame 043805/0616 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 6, 2017
From: BILJAN, TOMISLAV; WANG, YI; DOGAN, JASNA; RATKAJ, MARINA; SKUGOR, MAJA MATANOVIC; PIPERCIC, SARA MORASI
To: PLIVA HRVATSKA D.O.O.
Reel/Frame 043805/0694 →
ACKNOWLEDGEMENT OF RIGHTS
Recorded Oct 6, 2017
From: TEVA PHARMACEUTICAL INDUSTRIES, LTD.
To: PLIVA HRVATSKA D.O.O.
Reel/Frame 044143/0972 →
Continuity (7)
Provisional Application
62126840
· Mar 2, 2015
Provisional Application
62161421
· May 14, 2015
Provisional Application
62187668
· Jul 1, 2015
Provisional Application
62188992
· Jul 6, 2015
Provisional Application
62198218
· Jul 29, 2015
Provisional Application
62270310
· Dec 21, 2015
Cited By (1)