N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
The present invention provides compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.
1. A compound that is:
or a pharmaceutically acceptable salt or solvate thereof.
2. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
3. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
4. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
5. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
6. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
7. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
8. The compound of claim 1 that is:
or a pharmaceutically acceptable salt or solvate thereof.
9. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
10. A pharmaceutical composition comprising a compound of claim 2 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
11. A pharmaceutical composition comprising a compound of claim 3 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
12. A pharmaceutical composition comprising a compound of claim 4 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
13. A pharmaceutical composition comprising a compound of claim 5 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
14. A pharmaceutical composition comprising a compound of claim 6 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
15. A pharmaceutical composition comprising a compound of claim 7 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
16. A pharmaceutical composition comprising a compound of claim 8 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable carrier, diluent or excipient.