IP Library › Granted Patent US 10,368,750
Granted Patent B2
US 10,368,750 · App. 14/903,876 · Granted Aug 6, 2019

Shear wave imaging method and installation for collecting information on a soft solid

Inventors: Stefan Catheline (Lyons, FR); Jean-Yves Chapelon (Lyons, FR); Remi Souchon (Lyons, FR); Pol Grasland-Mongrain (Lyons, FR); Cyril Lafon (Lyons, FR)
Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale); Université Claude Bernard Lyon 1
A61B5/0051A61B5/05A61B5/055A61B5/0536A61B8/485G01R33/56358
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Quick Facts
Patent No.
US 10,368,750
App. No.
14/903,876
Granted
Aug 6, 2019
Kind
B2
Abstract

This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (f o ) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (Δf o ) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system ( 4, 7 ) for generating at least one shear wave (SW) in the target region (R) and a second system ( 10 ) for detecting a propagation pattern of the shear wave. The first system includes first means ( 4 ) to apply an electric field (E) through the target region (R) and second means ( 7 ) to apply a magnetic field (B) through the target region. The first and second means are configured to apply to particles of the target region some Lorentz forces resulting from the electric field (E) and the magnetic field (B), where at least one of these fields is a quantity variable in time, with a central frequency (f o ) between 1 Hz and 10 kHz, or both fields are quantities variable in time, with a central difference frequency (Δf o ) between 1 Hz and 10 kHz.

Claims (27)

1. Shear wave imaging method for collecting information on a target region of a soft solid, the method comprising at least the following steps:

a) generating at least one shear wave in the target region,

b) detecting a propagation pattern of the at least one shear wave in the target region

characterized in that

step a) is realized by applying to particles of the target region some Lorentz forces resulting from an electric field and from a magnetic field,

at least one of the electric field and the magnetic field is variable in time, with a central frequency between 1 Hz and 10 kHz or both the electric and magnetic fields are variable in time, with a central difference frequency between 1 Hz and 10 kHz.

2. The method according to claim 1 , wherein during step a), a first one of the electric field and the magnetic field is variable in time and the second one of the electric field and the magnetic field is constant in time.

3. The method according to claim 2 , wherein during step a), the electric field is variable in time and the magnetic field is constant in time.

4. The method according to claim 2 , wherein during step a), the magnetic field is variable in time and the electric field is constant in time.

5. The method according to claim 1 , wherein during step a), both the electric field and the magnetic field are variable in time, at frequencies between 1 and 10 kHz, or both the electric field and the magnetic field are variable in time at high frequencies, with a central difference frequency between 1 Hz and 10 kHz.

6. The method according to claim 1 , wherein the central frequency of the variable field or the central difference frequency is between 5 and 1000 Hz.

7. The method according to claim 1 , wherein the electric field is generated by two electrodes located on both sides, on one side or within the soft solid and connected to a source of electric current with an intensity between 1 μA and 1 A.

8. The method according to claim 1 , wherein the electric field is generated by a second magnetic field, variable in time.

9. The method according to claim 1 , wherein the soft solid is a biological tissue of human, animal or vegetal origin, preferably an organ, or an artificial medium.

10. The method according to claim 1 , wherein during step b), measurement of the shear wave propagation speed occurs via a sensor assembly based on ultrasound technology.

11. The method according to claim 1 , wherein during step b), measurement of the shear wave propagation speed occurs via a sensor assembly based on magnetic resonance imaging (MRI) technology.

12. The method according to claim 11 , wherein the magnetic field used during step a) is generated by the sensor assembly based on magnetic resonance imaging (MRI) technology.

13. The method according to claim 1 , wherein during step b) a source of the at least one shear wave is detected.

14. Shear wave imaging installation for collecting information of a target region of a soft solid, said shear wave imaging installation comprising:

a first system for generating at least one shear wave in the target region

a second system for detecting a propagation pattern of the at least one shear wave

characterized in that the first system includes

first means to apply an electric field through the target region and

second means to apply a magnetic field through the target region and in that the first and second means are configured to apply to particles of the target region Lorentz forces resulting from the electric field and the magnetic field, where at least one of the electric field and the magnetic field is a quantity variable in time, with a central frequency (f 0 ) between 1 Hz and 10 kHz, or both the electric and magnetic fields are quantities variable in time, with a central difference frequency between 1 Hz and 10 kHz.

15. The installation according to claim 14 , wherein the first means includes a set of electrodes installed on both sides, on one side or within the soft solid and connected to a source of electric current with an intensity between 1 μa and 1 A.

16. The method of claim 6 , wherein the central difference frequency is between 50 and 150 Hz.

17. The method of claim 9 , wherein the biological tissue is an organ.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 6, 2016
From: CATHELINE, STEFAN; CHAPELON, JEAN-YVES; SOUCHON, REMI; GRASLAND-MONGRAIN, POL; LAFON, CYRIL
To: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE CLAUDE BERNARD LYON 1
Reel/Frame 040534/0934 →
Priority Claims (1)
EP 13305987 · Jul 11, 2013 · regional
Continuity (1)
Related Publication 20160367143A1 · Dec 22, 2016