Cymanquine compounds and derivatives thereof and uses thereof
Organometallic compounds comprising a chloroquinoline moiety and uses the compounds. The compounds are, for example, manganese or rhenium complexes of a ligand comprising a chloroquinoline moiety. The compounds can be used in, for example, methods of inhibiting cell growth.
1. A compound having the formula:
where:
M is Mn or Re,
L is a neutral, two-electron donor ligand,
R 1 is an amine-substituted alkyl group,
R 2 is H, (CH 2 ) n CH 3 , wherein n is 0 to 20, OMe, OEt, OPh, Ph, CHO, COMe, COPh, CH 2 OH, CO 2 H, CO 2 Me, CO 2 Et, CH 2 Ph, NH 2 , NMe 2 , NEt 2 , C 6 H 4 Me, C 6 H 4 OMe, NH 2 COMe, F, Cl, Br, or I; and
E is a linker moiety connecting the cyclopentadienyl moiety with the chloroquinoline moiety.
2. The compound of claim 1 , wherein R 1 is (CH 2 ) n NR 3 R 4 , where n is an integer from 1 to 20 and R 3 and R 4 are independently H or an C 1 -C x alkyl group, wherein x is an integer from 2 to 20.
3. The compound of claim 1 , wherein L is selected from —CO, phosphines, phosphites, aryl amines, and carbenes.
4. The compound of claim 1 , wherein E is —NH(CH 2 ) n — or —NH(CH 2 ) n NHCH 2 —, wherein n is an integer from 1 to 10.
5. The compound of claim 1 , wherein a CO ligand is replaced by a second neutral, two-electron donor.
6. The compound of claim 1 , wherein M is Mn.
7. The compound of claim 1 , wherein M is Re.
8. The compound of claim 1 , wherein the compound has the following structure:
9. The compound of claim 1 , wherein the compound has the following structure:
10. A composition comprising one or more compounds of claim 1 and a pharmaceutical carrier.