Low power apparatus and method to measure complex electrical admittance or impedance
An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients includes a first electrode and at least a second electrode which are adapted to be disposed in the patient. The apparatus includes a housing adapted to be disposed in the patient. The housing has disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient.
1. An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients comprising:
two or more electrodes that are adapted to be disposed in the patient; and
a housing adapted to be disposed in the patient, the housing having disposed in it a stimulator in electrical communication with two or more electrodes to stimulate with either current or voltage an organ of the patient, the electrodes are placed in or on the organ, a sensor in electrical communication with the stimulating electrodes or with additional electrodes to sense a response based on the stimulation of the stimulating electrodes, and a signal processor in electrical communication with both the stimulator and the sensor to determine the complex electrical admittance of the patient with sinusoidal signals, the stimulator and the sensor and the signal processor together using an average current of less than 23 mA in operation over time, wherein a real part, and an imaginary part of admittance is measured to remove a muscle component of the patient from the complex admittance of the patient while removing a necessity to perform trigonometric calculations.
2. An apparatus as described in claim 1 wherein a real part, an imaginary part, a magnitude, and/or phase of admittance can be measured.
3. An apparatus described in claim 2 wherein a real part, an imaginary part, a magnitude, and/or phase of impedance can be measured.
4. An apparatus described in claim 3 wherein the stimulator produces an excitation wave that is a sinusoid at a single frequency, greater than 0 and less than or equal to 1 MHz.
5. An apparatus described in claim 3 wherein the stimulator produces an excitation wave that is two or more sinusoids with frequencies greater than 0 and less than or equal to 1 MHz.
6. An apparatus described in claim 3 wherein the stimulator produces an excitation wave that is any shape that can be defined by a repeated sequence of integer values, whose frequency components range from 0 to 1 MHz.
7. An apparatus described in claim 6 wherein the stimulator produces an excitation wave that is created by a resistor-summing network, called a SinDAC, such that a number of resistors, resistor values, digital output sequence, and rate of digital outputs are selected to define a shape and frequency of the excitation wave.
8. An apparatus described in claim 7 wherein an ADC conversion of the sensor is synchronized to the SinDAC outputs generating the stimulation.
9. An apparatus described in claim 8 wherein a Discrete Fourier Transform (DFT) is used by the signal processor to extract complex electrical properties.
10. An apparatus described in claim 4 wherein the complex measurements occurs with an analog circuit using a synchronous demodulator to directly measure either impedance or admittance.
11. An apparatus described in claim 9 or claim 10 wherein while measuring complex electrical properties 100 times a second requires less than 500 μA of current.
12. An apparatus described in claim 11 wherein while measuring complex electrical properties 50 times an hour requires less than 1 μA of current.
13. An apparatus described in claim 12 wherein the size of the housing is less than 2 cm by 2 cm by 0.4 cm.
14. An apparatus described in claim 13 wherein the electrodes are placed in or on the heart, which are used to estimate heart volume, stroke volume, change in heart volume, and/or change in stroke volume of the patient.
15. An apparatus described in claim 14 including a pressure sensor disposed on the lead, which is used to measure pressure volume loops in the heart.
16. An apparatus described in claim 15 including a wireless link and recording base station, which are used to remotely measure pressure, heart volume, stroke volume, change in heart volume, and/or change in stroke volume of the patient.
17. An apparatus described in claim 1 wherein the housing includes a pacemaker.
18. The apparatus of claim 1 wherein there is a variable distance between the two electrodes and the variable distance is incorporated into an equation to convert blood resistance to volume.
19. A method for measuring complex electrical admittance in animal or human patients comprising the steps of:
stimulating with a stimulator disposed in a housing disposed in the patient with two or more electrodes disposed in or on an organ of the patient with either current or voltage;
sensing with a sensor disposed in the housing with two or more sensing electrodes disposed in the patient to sense a response from the sensing electrodes based on the stimulation of the stimulating electrodes; and
determining with a signal processor disposed in the housing and in electrical communication with both the stimulator and the sensor the complex electrical admittance of the patient with sinusoidal signals, the stimulator and the sensor and the signal processor together using an average current of less than 23 mA in operation over time at a voltage less than 3.7 V, wherein a real part, and an imaginary part of admittance is measured to remove a muscle component of the patient from the complex admittance of the patient while removing a necessity to perform trigonometric calculations.
20. An apparatus for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients comprising:
a first electrode and at least a second electrode that are adapted to be disposed in or on an organ of the patient; and
a housing adapted to be disposed in the patient, the housing having disposed in it a stimulator in electrical communication with at least the first electrode to stimulate the first electrode with either current or voltage, a sensor in electrical communication with at least the second electrode to sense a response from the second electrode based on the stimulation of the first electrode, and a signal processor in electrical communication with the sensor to determine the complex electrical admittance or impedance of the patient with sinusoidal signals, the stimulator and the sensor and the signal processor together using an average current of less than 23 mA in operation over time, wherein a real part, and an imaginary part of admittance is measured to remove a muscle component of the patient from the complex admittance of the patient while removing a necessity to perform trigonometric calculations.
21. A method for measuring complex electrical admittance and/or complex electrical impedance in animal or human patients comprising the steps of:
stimulating with a stimulator disposed in a housing disposed in the patient with at least two stimulating electrodes disposed in or on an organ of the patient with either current or voltage;
sensing with a sensor disposed in the housing with at least two sensing electrodes disposed in the patient to sense a response from the sensing electrodes based on the stimulation of the simulating electrodes; and
determining with a signal processor disposed in the housing and in electrical communication with the sensor the complex electrical admittance or impedance of the patient with sinusoidal signals, the stimulator and the sensor and the signal processor together using an average current of less than 23 mA in operation over time, wherein a real part, an imaginary part of admittance is measured to remove a muscle component of the patient from the complex admittance of the patient while removing a necessity to perform trigonometric calculations.