Substituted heteroaryl aldehyde compounds and methods for their use in increasing tissue oxygenation

Inventors: Brian Metcalf (South San Francisco, CA); Chihyuan Chuang (South San Francisco, CA)

Assignee: Global Blood Therapeutics, Inc.

C07D401/12 C07D213/65 C07D213/68 C07D213/69 C07D213/80 C07D401/14 C07D405/14 C07D413/12 C07D471/04 C07D487/04

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Quick Facts

Patent No.: US 10,377,741
App. No.: 15/864,433
Granted: Aug 13, 2019
Kind: B2

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Abstract

Provided are substituted heteroaryl aldehydes and derivatives thereof that act as allosteric modulators of hemoglobin, methods and intermediates for their preparation, pharmaceutical compositions comprising the modulators, and methods for their use in treating disorders mediate by hemoglobin and disorders that would benefit from increased tissue oxygenation.

Claims (7)

1. A compound of formula:

or a salt thereof.

2. The compound of claim 1 , wherein the compound is:

3. A compound of formula:

or a salt thereof.

4. The compound of claim 3 , wherein the compound is:

5. The compound of claim 3 , wherein the salt is a hydrochloric acid salt.

Assignments (8)

RELEASE OF SECURITY INTEREST Recorded Oct 6, 2022

From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT

To: GLOBAL BLOOD THERAPEUTICS, INC.