IP Library Granted Patent US 10,398,293
Granted Patent B2
US 10,398,293 · App. 14/905,374 · Granted Sep 3, 2019

Optogenetic tool for multiple and independently addressing of patterned optical windows

Inventors: Ferruccio Pisanello (Lecce, IT); Luigi Martiradonna (London, GB); Leonardo Sileo (Calimera, IT); Ian Anton Oldenburg (Lexington, MA); Marco Pisanello (Felline di Alliste, IT); Bernardo Luis Sabatini (Newton, MA); John Abraham Assad (Brookline, MA); Massimo De Vittorio (Lecce, IT)
Assignees: Fondazione Istituto Italiano di Tecnologia; President and Fellows of Harvard College
A61B1/07A61B5/0084A61B18/22A61N5/062A61N5/0622G02B6/14G02B6/262A61B2018/2255A61B2018/2261A61B2562/0233A61N2005/063
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Quick Facts
Patent No.
US 10,398,293
App. No.
14/905,374
Granted
Sep 3, 2019
Kind
B2
Abstract

A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide. The waveguide comprises a tapered region along which the optical windows are distributed, wherein each optical window out-couples a specific subset of propagating modes of the carried light, to which the optical window is matched.

Claims (14)

1. A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide;

wherein said waveguide comprises a tapered region along which said optical windows are distributed, said tapered region comprising a tapered side surface, said multiple optical windows including a plurality of optical windows formed on said tapered side surface, wherein each optical window out-couples a specific subset of propagating modes of the carried light, to which said optical window is matched.

2. A device according to claim 1 , wherein said multiple optical windows further include an optical window formed on a tip of the tapered region of the waveguide.

3. A device according to claim 1 , wherein at least one of said optical windows is configured as a reservoir for containing a medical compound, said medical compound being optically deliverable by means of the light that is out-coupled by the optical window.

4. A device according to claim 1 , wherein said waveguide is a single optical fiber.

5. A device according to claim 1 , said device being provided for illuminating an optical sensitive material or environment, and being associated to an electrode array coupled to the waveguide for recording electric signals from the illuminated material or environment.

6. A device according to claim 5 , wherein said electrode array is arranged on said tapered side surface of said tapered region.

7. A device according to claim 1 , wherein said device is a neuronal interface tool implantable in a neuronal tissue.

8. A device according to claim 1 , wherein said device is an optogenetic device implantable in a tissue or biological system sensible to light.

9. A device according to claim 1 , wherein said device is a device for endoscopy or laser-based surgery.

10. A device according to claim 1 , wherein said tapered region has a taper angle between 1° and 10°.

11. A device according to claim 10 , wherein said tapered region has a taper angle between 3° and 6°.

12. A multi-point light-delivering device, comprising a waveguide carrying light along a longitudinal axis and including multiple optical windows, through which the carried light is out-coupled from the waveguide;

wherein said waveguide comprises a tapered region along which said optical windows are distributed, said tapered region comprising a tapered side surface and a tip, said optical windows including at least one optical window formed on said tapered side surface and a single optical window formed on said tip, wherein each optical window out-couples a specific subset of propagating modes of the carried light, to which said optical window is matched.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 24, 2018
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 046008/0655 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 25, 2016
From: PISANELLO, FERRUCCIO; MARTIRADONNA, LUIGI; SILEO, LEONARDO; OLDENBURG, IAN ANTON; PISANELLO, MARCO; SABATINI, BERNARDO LUIS; ASSAD, JOHN ABRAHAM; DE VITTORIO, MASSIMO
To: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA; PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 038807/0843 →
Priority Claims (1)
IT TO2013A0603 · Jul 17, 2013 · national
Continuity (1)
Related Publication 20160157706A1 · Jun 9, 2016
Cited By (1)
US 12,710,594