IP Library › Granted Patent US 10,416,163
Granted Patent B2
US 10,416,163 · App. 15/443,417 · Granted Sep 17, 2019

Method and treatment of recurring endometrial cancer with an inhibitor of USP14

Inventors: Martina Bazzaro (St. Paul, MN); Tanya Pulver (Minneapolis, MN); Rahel Ghebre (Golden Valley, MN); Rachel Isaksson Vogel (Eagan, MN)
Assignee: Regents of the University of Minnesota
G01N33/57442A61K31/55C12N9/485C12N15/1135C12N15/1137C12Q1/6886C12Y304/19012G01N33/57449C12N2310/12C12N2310/14G01N2333/948
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Quick Facts
Patent No.
US 10,416,163
App. No.
15/443,417
Granted
Sep 17, 2019
Kind
B2
Abstract

USP14 is a biomarker for recurrent disease and inhibition of USP14 is of therapeutic benefit for women with endometrial or ovarian cancer.

Claims (6)

1. A method to selectively treat a subject at risk of recurring endometrial cancer, which comprises selectively administering to the subject an agent which inhibits the activity of USP14, on the basis of said subject having previously been determined to have increased expression of USP14 in said cancer as compared to a control.

2. The method of claim 1 , wherein the agent is a protein, nucleic acid and/or small molecule.

3. The method of claim 2 , wherein the small molecule is VLX1570 or RA-9.

4. The method of claim 1 , further comprising surgery, chemotherapy, and/or radiation.

5. The method of claim 4 , wherein the surgery comprises lymph node dissection.

6. The method of claim 1 , wherein the cancer is chemoresistant.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 4, 2019
From: BAZZARO, MARTINA
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 050626/0219 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 6, 2019
From: PULVER, TANYA; GHEBRE, RAHEL; VOGEL, RACHEL ISAKSSON
To: REGENTS OF THE UNIVERSITY OF MINNESOTA
Reel/Frame 049970/0903 →
CONFIRMATORY LICENSE Recorded Mar 21, 2017
From: UNIVERSITY OF MINNESOTA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042045/0358 →
Continuity (2)
Provisional Application 62300494 · Feb 26, 2016
Related Publication 20170269091A1 · Sep 21, 2017