Polymeric metformin and its use as a therapeutic agent and as a delivery vehicle
Provided herein are polymers comprising Metformin residues (“PolyMet”) as useful therapeutic agents, delivery vehicles and transfection agents for nucleotides. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering PolyMet as a therapeutic agent to combat the disease or condition. Also provided herein are methods for the treatment of a disease or an unwanted condition in a subject, wherein the methods comprise administering a therapeutic agent in a delivery vehicle that comprises PolyMet. Further provided herein are methods for making PolyMet.
1. A nanoparticle comprising:
i. a lipid outer membrane; and
ii. a polymer encapsulated by the lipid outer membrane, said polymer having the following chemical formula I
wherein, p is 1 or 2, n is an integer from two (2) to 10,000;
and
wherein, X is hydrogen or a residue of Metformin having the formula:
wherein at least 5% of X in the polymer is a residue of Metformin.
2. The nanoparticle of claim 1 further comprising a cargo complexed with
the polymer, wherein the cargo is a therapeutic agent.
3. A method of delaying, inhibiting, decreasing, slowing or ameliorating type 2 diabetes or cancer by administering the nanoparticle of claim 1 to a subject.