Phytocomplexes exhibiting multiple, synergistic antioxidant activities useful in foods, dietary supplements, cosmetics and pharmaceutical preparations

1. An oxidative stress modulating composition comprising:

an amount of a combination of apple extract, grape extract, green tea extract, and olive extract at synergistic ratios that provides a greater combined antioxidant activity than provided by a sum of individual antioxidant activities of the individual components of the combination.

2. The composition of claim 1 , wherein the apple extract comprises an extract of a species Malus pumila.

3. The composition of claim 1 , wherein the grape extract comprises an extract of a species Vitis vinifera.

4. The composition of claim 1 , wherein the green tea extract comprises an extract of leaves of a species Camellia sinensis.

5. The composition of claim 1 , wherein the olive extract comprises an extract of a subspecies Olea europea.

6. The composition of claim 1 , wherein at least one of the extracts in the composition is present in a different amount than an amount of at least one of another extract.

7. The composition of claim 1 , wherein the apple, grape, green tea, and olive extracts are present in the composition at a weight ratio of about 1:1:1:1.

8. The composition of claim 1 , wherein the apple, grape, green tea, and olive extracts are present in the composition at a weight ratio of about 6:1:3:1.

9. The composition of claim 1 , wherein the apple, grape, green tea, and olive extracts comprise leaves, skin, rind, pulp, juice, seeds, or combinations thereof.

10. The composition of claim 1 , further comprising at least one primary or secondary therapeutic agent.

11. The composition of claim 10 , wherein the at least one primary or secondary therapeutic agent comprises a member selected from the group consisting of bergamot, mangosteen, berberine, arginine, citrulline, glutamine, zinc, beet, protein, curcumin, phytosterols, fish oil, CoQ10, vitamins, fiber, inulin, and combinations thereof.

12. The composition of claim 10 , wherein the at least one primary or secondary therapeutic agent comprises bergamot.

13. The composition of claim 10 , wherein the at least one primary or secondary therapeutic agent comprises mangosteen.

14. The composition of claim 10 , wherein the at least one primary or secondary therapeutic agent comprises berberine.

15. The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.

16. The composition of claim 1 , wherein the composition is an oral dosage formulation.

17. The composition of claim 16 , wherein the oral dosage form comprises a capsule, a tablet, a powder, a beverage, a syrup, a suspension, or a food.

18. The composition of claim 1 , wherein the antioxidant activity modulates stress related pathologies and metabolic disorders.

19. The composition of claim 1 , wherein the antioxidant activity modulates oxidized LDL.

20. The composition of claim 1 , further comprising blueberry concentrate, capsicum extract, and turmeric extract.

21. The composition of claim 20 , wherein the blueberry concentrate comprises Vaccinium angustifolium , the capsicum extract comprises Capsicum annuum , and the turmeric extract comprises Curcuma longa.

22. The composition of claim 20 , further comprising mangosteen fruit extract.

23. The composition of claim 22 , wherein the composition comprises greater than 1.5 times the antioxidant activity of an equivalent amount of any one extract or concentrate or a sum of the extracts and concentrate.

24. The composition of claim 20 , further comprising bergamot extract.

25. The composition of claim 24 , wherein the bergamot extract comprises Citrus bergamia Risso.

26. The composition of claim 25 , wherein the composition comprises greater than 1.5 times the antioxidant activity of an equivalent amount of any one extract or concentrate or a sum of the extracts and concentrate.

27. The composition of claim 20 , further comprising a mangosteen pericarp extract.

28. The composition of claim 27 , wherein the composition comprises greater than 1.25 times the antioxidant activity of an equivalent amount of any one extract or concentrate or a sum of the extracts and concentrate.

29. The composition of claim 20 , further comprising mangosteen pericarp extract and bergamot extract.

30. A method of regulating oxidative stress in a subject comprising:

administering to the subject a therapeutically effective combination of apple, grape, green tea, and olive extracts, in amounts that provide a combined antioxidant activity that is greater than an antioxidant activity provided by an equivalent amount of any one extract or a sum of the extracts.

31. The method of claim 30 , wherein;

the apple extract comprises an extract of skin and fruit of Malus pumila;

the grape extract comprises an extract of seeds of Vitis vinifera;

the green tea extract comprises an extract of leaves of Camellia sinensis ; and

the olive extract comprises leaves of Olea europea europaea.

32. The method of claim 30 , wherein the apple, grape, green tea, and olive extracts are present at a weight ratio of about 1:1:1:1.

33. The method of claim 30 , wherein the apple, grape, green tea, and olive extracts are present at a weight ratio of about 6:1:3:1.

34. The method of claim 30 , further comprising administering to the subject at least one secondary therapeutic agent.

35. The method of claim 34 , wherein the at least one secondary therapeutic agent is co-administered to the subject with the therapeutically effective combination of apple, grape, green tea, and olive extracts.

36. The method of claim 34 , wherein the at least one secondary therapeutic agent comprises a member selected from the group consisting of bergamot, mangosteen, berberine, arginine, citrulline, glutamine, zinc, beet, loclo, protein, curcumin, phytosterols, fish oil, CoQ10, vitamins, fiber, inulin, and combinations thereof.

37. The method of claim 30 , wherein the antioxidant activity modulates stress related pathologies and metabolic disorders.