Notch pathway signaling inhibitor compounds
The present invention provides the following compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing said compounds useful as a Notch pathway signaling inhibitor for the treatment of named cancers, sensorineural hearing loss caused by auditory hair cell loss, and inducing auditory hair cell generation.
1. A compound of the structure:
or a pharmaceutically acceptable salt thereof.
2. A compound of the structure:
or a pharmaceutically acceptable salt thereof.
3. A pharmaceutical composition comprising the compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
4. A method of treating colorectal cancer in a patient comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
5. A method of treating sensorineural hearing loss caused by auditory hair cell loss in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
6. A method of inducing auditory hair cell generation in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
7. A pharmaceutical composition comprising the compound of claim 2 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
8. A method of treating colorectal cancer in a patient comprising administering to a patient in need thereof a therapeutically effective amount of the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
9. A method of treating sensorineural hearing loss caused by auditory hair cell loss in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
10. A method of inducing auditory hair cell generation in a patient in need thereof, comprising administering to said patient a therapeutically effective amount of the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
11. A substantially pure diastereomer of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
12. A substantially pure diastereomer of the compound of claim 2 , or a pharmaceutically acceptable salt thereof.