Embolic implant and method of use
A parent artery occlusion (PAO) device which provides for immediate occlusion of a cerebral artery to isolate a defect. The PAO device includes a self-expanding wire-frame prolate structure which is partially covered with an ePTFE membrane.
1. An embolic implant comprising:
a wire frame structure comprising:
a pair of opposing zigzag segments including a plurality of V-shaped elements defining an open end, the V-shaped elements joined at the open end of the V-shaped elements via struts to form a central portion of the wire frame structure, the V-shaped elements defining proximal or distal vertices pointing proximally or distally away from a longitudinal center of the wire frame structure;
a first plurality of longitudinally oriented struts extending from the proximally pointing vertices of the V-shaped elements, the first plurality of longitudinally oriented struts being joined together near a radial center of the wire frame structure at a proximal end of the wire frame structure; and
a second plurality of longitudinally oriented struts extending from the distally pointing vertices of the V-shaped elements, the second plurality of longitudinally oriented struts being joined together near the radial center of the wire frame structure at a distal end of the embolic implant; and
a blood impermeable membrane covering at least a part of the wire frame structure extending from the proximal end of the wire frame structure to at least distal to the longitudinal center of the wire frame structure.
2. The system of claim 1 , wherein the struts joining the V-shaped elements are longitudinally displaced from each other.
3. The system of claim 1 , wherein the proximal vertices of the V-shaped elements are not circumferentially aligned.
4. The system of claim 1 , further comprising:
a first ring joining the first plurality of the longitudinally oriented struts together at the proximal end of the wire frame structure; and
a second ring joining the second plurality of the longitudinally oriented struts together at the distal end of the wire frame structure.
5. The system of claim 4 , wherein at least one of the first ring or the second ring comprises a radiopaque material.
6. The system of claim 1 , the blood impermeable membrane partially covering the wire frame structure, and the membrane comprising a proximal facing surface and a circumferential facing surface, wherein at least the proximal facing surface is blood impermeable.
7. The system of claim 6 , wherein the proximal facing surface and the circumferential facing surface are blood impermeable.
8. The system of claim 6 , wherein the blood impermeable membrane is perforated with weep holes.
9. The system of claim 6 , wherein the blood impermeable membrane comprises expanded polytetrafluoroethylene (ePTFE) impregnated with an adhesive, the membrane being glued to the wire frame structure.
10. The system of claim 6 , wherein the blood impermeable membrane comprises two layers of expanded polytetrafluoroethylene (ePTFE) impregnated with an adhesive, the membrane being glued to the wire frame structure.
11. The system of claim 1 , wherein the wire frame structure is at least partially formed from a pseudoelastic metal alloy.
12. The system of claim 1 , wherein the wire frame structure is configured to expand from a compacted configuration to a fully expanded configuration, wherein when the wire frame structure is in the fully expanded configuration, the wire frame structure has a maximum diameter of about 5 millimeters, and when the wire frame structure is in the compacted configuration, the wire frame structure has a maximum diameter of less than about 0.6 mm.
13. The system of claim 1 , further comprising a delivery member, wherein the wire frame structure is releasably attached to the delivery member.
14. The system of claim 13 , further comprising a detachment joint releasably joining a proximal end of the wire frame structure to the delivery member.
15. The system of claim 14 , wherein the detachment joint is an electrolytic detachment joint.
16. A method for occluding an artery, the method comprising:
advancing a delivery catheter through vasculature of a patient, wherein the delivery catheter houses an embolic implant within a distal tip of the delivery catheter, the embolic implant comprising:
a self-expanding wire frame structure comprising:
a pair of opposing zigzag segments including a plurality of V-shaped elements defining an open end, the V-shaped elements joined at the open end of the V-shaped elements via struts to form a central portion of the wire frame structure, the V-shaped elements defining proximal or distal vertices pointing proximally or distally away from a longitudinal center of the wire frame structure;
a first plurality of longitudinally oriented struts extending from the proximally pointing vertices of the V-shaped elements, the longitudinally oriented struts being joined together near a radial center of the wire frame structure at a proximal end of the embolic implant; and
a second plurality of longitudinally oriented struts extending from the distally pointing vertices of the V-shaped elements, the longitudinally oriented struts being joined together near the radial center of the wire frame structure at a distal end of the embolic implant; and
a blood impermeable membrane covering at least a part of the wire frame structure extending from the proximal end of the wire frame structure to at least distal to the longitudinal center of the wire frame structure; and
withdrawing the delivery catheter.
17. The method of claim 16 , wherein withdrawing the delivery catheter releases the embolic implant from the delivery catheter.
18. The method of claim 16 , further comprising releasing the embolic implant from a delivery member disposed within the delivery catheter.
19. The method of claim 18 , wherein the embolic implant is attached to the delivery member via a detachment joint, and wherein releasing the embolic implant from the delivery member comprises controlling a device to deliver electric current to the detachment joint to sever the detachment joint and release the embolic implant from the delivery catheter.
20. The method of claim 16 , further comprising:
drawing the embolic implant back into the delivery catheter; and
repositioning the embolic implant within the vasculature.
21. The method of claim 16 , further comprising delivering a drug or therapeutic agent to the patient via the delivery member.
22. The method of claim 16 , wherein the delivery catheter comprises a first catheter, the method further comprising delivering a drug or therapeutic agent to the patient via a second catheter.