Substituted phenothiazines as mitochondrial agents
The present disclosure provides phenothiazine derivative compounds and salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
1. A compound selected from the group consisting of:
2. The compound of claim 1 , wherein the compound is selected from the group consisting of:
3. The compound of claim 1 , wherein the compound is selected from the group consisting of:
4. The compound of claim 1 , wherein the compound is selected from the group consisting of:
5. The compound of claim 1 , wherein the compound is selected from the group consisting of:
6. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier, excipient and/or diluent.
7. A compound:
8. A pharmaceutical composition comprising the compound according to claim 7 and a pharmaceutically acceptable carrier, excipient and/or diluent.