IP Library Granted Patent US 10,472,385
Granted Patent B2
US 10,472,385 · App. 15/101,189 · Granted Nov 12, 2019

Triterpene-glycosides as sweeteners or sweetener enhancers

Inventors: Karsten Siems (Michendorf, DE); Grit Kluge (Trebbin, DE); Sven Jakupovic (Berlin, DE); Gregor Hetterling (Berlin, DE); Fotini Tschirintzi (Berlin, DE)
Assignee: Analyticon Discovery GmbH
C07J17/005A23G3/36A23G4/06A23G4/08A23L27/00A23L27/30A23L27/36A61K8/602A61Q11/00A23V2002/00
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Quick Facts
Patent No.
US 10,472,385
App. No.
15/101,189
Granted
Nov 12, 2019
Kind
B2
Abstract

Suggested are triterpene-glycoside compounds, which are obtainable by the extraction of Momordica grosvenorii ( Siraitia grosvenori ) which are useful as a sweetener or sweetener enhancer in preparations and compositions, especially oral edible compositions.

Claims (12)

1. A method of sweetening or enhancing sweetening effect, comprising

incorporating a sweetener compound of the following formula (I)

wherein R 1 is glucopyranosyl, R 2 is glucopyranosyl-1-(1→2)-[glucopyranosyl-(1→6)]-glucopyranosyl, and R 3 denotes hydrogen,

into a composition to sweeten or enhance the sweeting effect in the composition.

2. A method according claim 1 , wherein the compound of formula (I) is

2-(4,5-dihydroxy-2-(2-hydroxy-2-methyl-6-(4,4,9,13,14-pentamethyl-3-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptan-3-yloxy)-6-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (compound E).

3. A method according to claim 1 , comprising the additional step of adding aroma compounds and/or flavouring agents and/or sweeteners and/or sweet-tasting substances.

4. A method according to claim 1 , wherein the sweetener is an extract obtained aqueous and/or alcoholic extraction of the plant Momordica grosvenorii ( Synononym Siraitia grosvenori ).

5. A method according to claim 4 , wherein the compound of formula (I) is

(2S,3R,4S,5S,6R)-2-((2S,3R,4S,5S,6R)-4,5-dihydroxy-2-((3R,6R)-2-hydroxy-2-methyl-6-((3S,8R,9R,13R,14S,17R)-4,4,9,13,14-pentamethyl-3-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)heptan-3-yloxy)-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (compound Ee).

6. A method according to claim 1 , comprising the additional step of

administering the composition to an individual in an effective amount sufficient to produce the desired degree of sweetness.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 11, 2016
From: SIEMS, KARSTEN; KLUGE, GRIT; JAKUPOVIC, SVEN; HETTERLING, GREGOR; TSCHIRINTZI, FOTINI
To: ANALYTICON DISCOVERY GMBH
Reel/Frame 039124/0885 →
Continuity (1)
Related Publication 20170029458A1 · Feb 2, 2017