Environmentally preferred antimicrobial compositions
Provided are antimicrobial compositions that include a hydrogen peroxide generator, a peracid catalyst, a sugar acid lactone selected from among a gluconolactone, a galactonolactone, a mannonolactone, a gulonolactone and a combination thereof in an amount from about 10 wt % to about 60 wt %, an acetate, and a carboxylic acid, where the ratio between the hydrogen peroxide generator and the peracetic acid catalyst is from about 1.5:1 to about 3:1 respectively. The compositions have increased shelf life and storage stability. The antimicrobial compositions can be formulated into a disinfection solution. Also provided are methods of disinfecting a surface that include applying the disinfecting solution to a surface, resulting in the destruction of a microbe on the surface.
1. An antimicrobial composition, comprising:
a homogeneous blend comprising in dry form:
a hydrogen peroxide generator;
a peracid catalyst;
a sugar acid lactone selected from the group consisting of a gluconolactone, a galactonolactone, a mannonolactone, a gulonolactone, and a combination thereof in an amount from about 10 wt % to about 60 wt %;
an acetate; and
a carboxylic acid,
wherein the homogeneous blend is formed into a compressed tablet; and wherein:
the ratio of the hydrogen peroxide generator to the peracid catalyst is between 1.5:1 and 3:1 respectively; and
the initial pH of an aqueous solution of the composition upon dissolution is alkaline so that the peracid catalyst is exposed to an alkaline pH to promote formation of a peracid in situ, and the pH of the solution automatically reduces to a pH of about 7 or less within 24 hours at room temperature to stabilize the in situ formed peracid.
2. The composition of claim 1 , wherein:
the hydrogen peroxide generator comprises an alkali metal perborate, alkali metal percarbonate, alkali metal perphosphate, alkali metal persilicate or alkali metal persulfate or a combination thereof; or
the hydrogen peroxide generator is sodium percarbonate, calcium peroxide, urea peroxide, sodium persulfate, potassium monopersulfate or a combination thereof.
3. The composition of claim 1 , wherein:
the peracid catalyst is an agent that contains an acetyl donor group or an acyl donor group or a combination thereof, wherein the agent contains an —O—C(O)CH 3 donor group, an —N—C(O)CH 3 donor group, an —O—C(O)R 1 ) donor group or an —N—C(O)R 2 donor group, wherein R 1 and R 2 each individually is C 1 to C 20 alkyl; or
the peracid catalyst is selected from the group consisting of monoacetin, diacetin, triacetin, glucose pentaacetate, lactose octaacetate, mannitol hexaacetate, sucrose octaacetate, N,N,N′N′-tetraacetylethylene-diamine (TAED), N,N,N′N′-tetraacetylmethylene-diamine (TAMD), N-acetyl glycine, N-acetyl-methionine, 6-acetamidohexanoic acid, N-acetyl-L-cysteine, 4-acetamido-phenol, N-acetyl-L-glutamine, and N,N′,N″,N′″-tetraacetyl glycoluril (TAGU).
4. The composition of claim 1 , wherein the sugar acid lactone is glucono-delta-lactone.
5. The composition of claim 1 , wherein the hydrogen peroxide generator is present in an amount of from about 40 wt % to about 60 wt %.
6. The composition of claim 1 , wherein the peracid catalyst is present in an amount from about 15 wt % to about 30 wt %.
7. The composition of claim 1 , wherein the carboxylic acid is present in an amount from about 5 wt % to about 25 wt %.
8. The composition of claim 1 that:
is contained in a water soluble pouch; or
further comprises a protective layer comprising an acrylic, a sugar, a starch, a malto-dextrin, a polyethylene glycol, a film forming water soluble polymer or a combination thereof.
9. The composition of claim 1 , wherein:
the carboxylic acid is a straight chain aliphatic carboxylic acid or a branched chain aliphatic carboxylic acid; or
the carboxylic acid is selected from the group consisting of acetic acid, citric acid, formic acid, gluconic acid, glycolic acid, lactic acid, maleic acid, malic acid, oxalic acid, succinic acid and tartaric acid.
10. The composition of claim 1 , further comprising an effervescence generator.
11. The composition of claim 1 , further comprising a color indicator that changes color when the pH changes from alkaline to more acidic in an amount from about 0.005 wt % to about 1.0 wt % based on the weight of the composition.
12. The composition of claim 1 , wherein:
the hydrogen peroxide generator is sodium percarbonate;
the peracid catalyst is N,N,N′N′-tetraacetylethylenediamine (TAED);
the sugar acid lactone is glucono-delta-lactone; and
the carboxylic acid is citric acid.
13. The composition of claim 12 , further comprising a surfactant.
14. The composition of claim 1 , further comprising one or more of an additional component selected from the group consisting of an organic solvent, a surfactant, a buffering salt, a tablet lubricant, a fragrance, a colorant, a chelant, an enzyme, an acid, a carbonate, a bicarbonate, a phosphate, a wetting agent, a dispersing agent, a hydrotrope, a rheology control agent, a foam suppressant, a metal protectant, and a corrosion inhibitor, present in an amount from 0.05% to 75% based on the weight of the tablet.
15. The composition of claim 1 , further comprising:
a surfactant; and
a chelating agent.
16. The composition of claim 1 , further comprising a polyglycol, a polyalkylene glycol, a methoxypolyalkylene glycol, a polyglycol copolymer or a combination thereof.
17. A solution, comprising:
from about 50 wt % to about 99.95 wt % of a solvent; and
from about 0.05 wt % to about 50 wt % of the composition of claim 1 dissolved in the solvent.
18. A method of disinfecting a surface, comprising:
dissolving the composition of claim 1 in a solvent to form a disinfecting solution; and
applying the disinfecting solution to the surface resulting in the destruction of a microbe on the surface.
19. The composition of claim 1 , wherein the peracid catalyst is present in an amount from about 15 wt % to about 35 wt %.