Data processing system and program for chromatograph mass spectrometer

1. A data processing system for a chromatograph mass spectrometer which creates a chromatogram based on a temporal change in a mass spectrum acquired over a mass-to-charge-ratio range including a target mass-to-charge ratio used for a quantitative determination of a target component, the system comprising:

a) a first mass chromatogram creator for creating a first mass chromatogram which shows a temporal change in a signal intensity at the target mass-to-charge ratio;

b) a correction mass-to-charge ratio designator for determining whether or not the signal intensity at a peak top of a target peak which is a peak corresponding to the target component on the first mass chromatogram is equal to or higher than a predetermined threshold, and for designating, as a correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a signal intensity lower than the predetermined threshold on a mass spectrum corresponding to an occurrence time of the aforementioned peak top if the signal intensity at the peak top is equal to or higher than the predetermined threshold;

c) a correction mass spectrum acquirer for acquiring a correction mass spectrum which is the mass spectrum at a point in time where the signal intensity does not exceed the threshold within the target peak;

d) a sensitivity factor calculator for calculating a sensitivity factor which is the signal intensity at the target mass-to-charge ratio on the correction mass spectrum divided by the signal intensity at the correction mass-to-charge ratio on the same correction mass spectrum;

e) a second mass chromatogram creator for creating a second mass chromatogram which shows a temporal change in the signal intensity at the correction mass-to-charge ratio; and

f) a corrected mass chromatogram creator for creating a corrected mass chromatogram by multiplying the second mass chromatogram by the sensitivity factor.

2. The data processing system for a chromatograph mass spectrometer according to claim 1 , wherein the correction mass-to-charge ratio designator designates, as the correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a highest signal intensity among peaks whose signal intensities are lower than the threshold.

3. A data processing system for a chromatograph mass spectrometer which creates a chromatogram based on a temporal change in a mass spectrum acquired over a mass-to-charge-ratio range including a target mass-to-charge ratio used for a quantitative determination of a target component, the system comprising:

a) a first mass chromatogram creator for creating a first mass chromatogram which shows a temporal change in a signal intensity at the target mass-to-charge ratio;

b) a correction mass-to-charge ratio designator for determining whether or not the signal intensity at a peak top of a target peak which is a peak corresponding to the target component on the first mass chromatogram is equal to or higher than a predetermined threshold, and for designating, as a correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a signal intensity lower than the predetermined threshold on a mass spectrum corresponding to an occurrence time of the aforementioned peak top if the signal intensity at the peak top is equal to or higher than the predetermined threshold;

c) a correction mass spectrum acquirer for acquiring a correction mass spectrum which is the mass spectrum at a point in time where the signal intensity does not exceed the threshold within the target peak;

d) a sensitivity factor calculator for calculating a sensitivity factor which is the signal intensity at the target mass-to-charge ratio on the correction mass spectrum divided by the signal intensity at the correction mass-to-charge ratio on the same correction mass spectrum;

e) a second mass chromatogram creator for creating a second mass chromatogram which shows a temporal change in the signal intensity at the correction mass-to-charge ratio;

f) a corresponding peak height/area calculator for calculating a height or area of a corresponding peak which is a peak appearing on the second mass chromatogram and at a same point in time as the target peak; and

g) a corrected peak height/area calculator for calculating a corrected peak height or corrected peak area by multiplying the height or area of the corresponding peak by the sensitivity factor.

4. The data processing system for a chromatograph mass spectrometer according to claim 3 , wherein the correction mass-to-charge ratio designator designates, as the correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a highest signal intensity among peaks whose signal intensities are lower than the threshold.

5. A non-transitory computer readable medium recording a program for a data processing system for a chromatogram mass spectrometer which creates a chromatogram based on a temporal change in a mass spectrum acquired over a mass-to-charge-ratio range including a target mass-to-charge ratio used for a quantitative determination of a target component, the program making a computer function as:

a) a first mass chromatogram creator for creating a first mass chromatogram which shows a temporal change in a signal intensity at the target mass-to-charge ratio;

b) a correction mass-to-charge ratio designator for determining whether or not the signal intensity at a peak top of a target peak which is a peak corresponding to the target component on the first mass chromatogram is equal to or higher than a predetermined threshold, and for designating, as a correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a signal intensity lower than the predetermined threshold on a mass spectrum corresponding to an occurrence time of the aforementioned peak top if the signal intensity at the peak top is equal to or higher than the predetermined threshold;

c) a correction mass spectrum acquirer for acquiring a correction mass spectrum which is the mass spectrum at a point in time where the signal intensity does not exceed the threshold within the target peak;

d) a sensitivity factor calculator for calculating a sensitivity factor which is the signal intensity at the target mass-to-charge ratio on the correction mass spectrum divided by the signal intensity at the correction mass-to-charge ratio on the same correction mass spectrum;

e) a second mass chromatogram creator for creating a second mass chromatogram which shows a temporal change in the signal intensity at the correction mass-to-charge ratio; and

f) a corrected mass chromatogram creator for creating a corrected mass chromatogram by multiplying the second mass chromatogram by the sensitivity factor.

6. The non-transitory computer readable medium recording a program according to claim 5 , wherein the correction mass-to-charge ratio designator designates, as the correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a highest signal intensity among peaks whose signal intensities are lower than the threshold.

7. A non-transitory computer readable medium recording a program for a data processing system for a chromatogram mass spectrometer which creates a chromatogram based on a temporal change in a mass spectrum acquired over a mass-to-charge-ratio range including a target mass-to-charge ratio used for a quantitative determination of a target component, the program making a computer function as:

a) a first mass chromatogram creator for creating a first mass chromatogram which shows a temporal change in a signal intensity at the target mass-to-charge ratio;

b) a correction mass-to-charge ratio designator for determining whether or not the signal intensity at a peak top of a target peak which is a peak corresponding to the target component on the first mass chromatogram is equal to or higher than a predetermined threshold, and for designating, as a correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a signal intensity lower than the predetermined threshold on a mass spectrum corresponding to an occurrence time of the aforementioned peak top if the signal intensity at the peak top is equal to or higher than the predetermined threshold;

c) a correction mass spectrum acquirer for acquiring a correction mass spectrum which is the mass spectrum at a point in time where the signal intensity does not exceed the threshold within the target peak;

d) a sensitivity factor calculator for calculating a sensitivity factor which is the signal intensity at the target mass-to-charge ratio on the correction mass spectrum divided by the signal intensity at the correction mass-to-charge ratio on the same correction mass spectrum;

e) a second mass chromatogram creator for creating a second mass chromatogram which shows a temporal change in the signal intensity at the correction mass-to-charge ratio;

f) a corresponding peak height/area calculator for calculating a height or area of a corresponding peak which is a peak appearing on the second mass chromatogram and at a same point in time as the target peak; and

g) a corrected peak height/area calculator for calculating a corrected peak height or corrected peak area by multiplying the height or area of the corresponding peak by the sensitivity factor.

8. The non-transitory computer readable medium recording a program according to claim 7 , wherein the correction mass-to-charge ratio designator designates, as the correction mass-to-charge ratio, a mass-to-charge ratio of a peak showing a highest signal intensity among peaks whose signal intensities are lower than the threshold.