Methods, systems, and devices relating to open microfluidic channels
Various collection devices, systems and methods relating to the use of devices with open microfluidic channels disposed within a housing defining a lumen. These devices make use of microneedles passed through apertures to induce fluid flow into microfluidic channel networks for collection and analysis. The device can be actuated via button when placed on the skin of a patient to collect a fluid sample, such as a blood draw.
1. A fluid collection device for use on the skin of a subject, the fluid collection device comprising:
a housing defining a lumen, wherein the housing includes a base having
a distal surface configured to be positioned adjacent to the skin of the subject;
an aperture extending through the base and configured to receive fluid from the subject therethrough; and
a microfluidic channel positioned to be in fluid communication with the aperture, wherein the microfluidic channel is sized and shaped to receive and direct the fluid upward and away from the aperture via spontaneous capillary flow,
wherein the microfluidic channel includes a base surface and an elongate opening over the base surface, and wherein the elongate opening is open to the lumen of the housing, and further wherein at least a portion of the base surface slopes upward at an acute angle relative to the distal surface.
2. The fluid collection device of claim 1 , further comprising an actuator movably positioned at least partially within the lumen of the housing.
3. The fluid collection device of claim 2 , further comprising a lancet operably coupled to the actuator, wherein the actuator is movable to urge the lancet through the aperture.
4. The fluid collection device of claim 1 wherein the microfluidic channel has a U-shaped cross-section.
5. The fluid collection device of claim 1 wherein the aperture extends along an axis, and wherein a portion of the microfluid channel adjacent to the aperture extends perpendicular to the axis.