Immunogenic rhinovirus peptides
Fusion proteins comprising a carrier protein and a Human Rhinovirus (HRV) peptide, and immunogenic compositions containing such fusion proteins.
1. An immunogenic composition comprising (a) a fusion protein, said fusion protein comprising a carrier protein coupled to a human rhinovirus (HRV) peptide of no more than 40 amino acids, said HRV peptide comprising a sequence selected from SEQ ID NO: 1; and (b) a pharmaceutically acceptable diluent, excipient or carrier.
2. The immunogenic composition of claim 1 , wherein said carrier protein is CRM197.
3. The immunogenic composition of claim 1 , further comprising an adjuvant.
4. The immunogenic composition of claim 3 , wherein said adjuvant comprises QS21.
5. The immunogenic composition of claim 3 , wherein said adjuvant comprises 3D-MPL and QS21 in a liposome formulation.
6. A fusion protein comprising a carrier protein coupled to a HRV peptide of no more than 40 amino acids, said HRV peptide comprising a sequence selected from SEQ ID NO: 1.
7. The fusion protein of claim 6 , wherein said carrier protein is CRM197.
8. A method for preparing an immunogenic composition, the method comprising combining (a) a fusion protein comprising a carrier protein coupled to a human rhinovirus (HRV) peptide of no more than 40 amino acids, said HRV peptide comprising a sequence selected from SEQ ID NO: 1; and (b) a pharmaceutically acceptable diluent, excipient, or carrier.
9. The method of claim 8 , wherein said carrier protein is CRM197.
10. The method of claim 8 , further comprising combining (c) an adjuvant.
11. The method of claim 10 , wherein said adjuvant comprises QS21.
12. The method of claim 10 , wherein said adjuvant comprises 3D-MPL and QS21 in a liposome formulation.