Processes for the preparation of uracil derivatives
The present invention relates to processes and intermediates for preparing Gonadotropin-Releasing Hormone (GnRH) receptor antagonists of structure (VI); and stereoisomers and pharmaceutically acceptable salts thereof.
1. A compound of structure (VII)
wherein:
R 2a and R 2b are the same or different and independently halogen, trifluoromethyl, cyano or —SO 2 CH 3 ; and
R 3 is hydrogen or methyl.
2. The compound of claim 1 wherein R 2a is F and R 2b is —CF 3 .
3. The compound of claim 2 wherein R 3 is hydrogen.
4. A compound of structure (VII)
wherein:
R 2a and R 2b are different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO 2 CH 3 ; and
R 3 is hydrogen or methyl.
5. The compound of claim 4 wherein R 2a is F.
6. The compound of claim 5 wherein R 3 is methyl.
7. The compound of claim 4 wherein R 2b is −CF 3.
8. The compound of claim 7 wherein R 3 is methyl.