Peptides for prevention of HIV infection
Two peptides that can selectively bind to SEVI and block the enhanced infectivity that results from the interaction of SEVI with HIV. The two peptides comprise the amino acid sequences FEEIVQEIEDFLENLV (SEQ. ID NO: 1) and GIGAVLEVLTTGLPALISWIEEEEQQ (SEQ. ID. NO: 2). The peptides may be administered topically, either alone or in combination with other prophylactics, agents, etc.
1. A compound, comprising an artificial peptide sequence that binds to semen enhancer of virus infection (SEVI) amyloid fibrils of prostatic acid phosphatase (PAP) but does not bind to non-aggregated PAP, wherein the artificial peptide sequence is selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2.
2. The compound of claim 1 , wherein the artificial peptide sequence is SEQ ID NO: 1.
3. The compound of claim 2 , wherein the artificial peptide sequence is SEQ ID NO: 2.
4. A composition comprising the compound of claim 1 combined with a prophylactic.
5. A composition comprising the compound of claim 1 combined with a topical agent.
6. A combination product, comprising a first artificial peptide sequence that binds to semen enhancer of virus infection (SEVI) amyloid fibrils of prostatic acid phosphatase (PAP) but does not bind to non-aggregated PAP combined with a second artificial peptide sequence that binds to SEVI but does not bind to non-aggregated PAP, wherein the first artificial peptide sequence is SEQ ID NO: 1 and the second artificial peptide sequence is SEQ ID NO: 2.
7. The combination product of claim 6 , wherein the first artificial peptide sequence and the second artificial peptide sequence are combined with a topical agent.
8. The combination product of claim 6 , wherein the first artificial peptide sequence and the second artificial peptide sequence are combined with a prophylactic.