IP Library › Granted Patent US 10,519,157
Granted Patent B2
US 10,519,157 · App. 16/270,728 · Granted Dec 31, 2019

Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof

Inventors: Hui Joyce Li (Westborough, MA); Shuhao Wen (Andover, MA); Changfu Cheng (Northborough, MA); Xiao Chen (Princeton, NJ); Gao Shang (Doylestown, PA)
Assignee: X-CUTAG THERAPEUTICS, INC.
C07D471/08C07B2200/05
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Quick Facts
Patent No.
US 10,519,157
App. No.
16/270,728
Granted
Dec 31, 2019
Kind
B2
Abstract

Novel deuterium-containing chemical compounds are provided. They are glucosylceramide (GSC) synthase inhibitors and are useful for treating various types of lysosomal storage diseases including Fabry's disease, Gaucher's disease and Parkinson's disease, or related diseases and conditions. Also described are pharmaceutical compositions, and methods of preparation and use thereof.

Claims (3)

1. A compound of the following Formula (II):

2. A compound of the following Formula (III):

3. A compound of the following Formula (IV):

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2019
From: LI, HUI JOYCE; WEN, SHUHAO; CHENG, CHANGFU; CHEN, XIAO; SHANG, GAO
To: X-CUTAG THERAPEUTICS, INC.
Reel/Frame 048274/0878 →
Continuity (2)
Provisional Application 62628458 · Feb 9, 2018
Related Publication 20190248790A1 · Aug 15, 2019