Zinc amino acid halide mouthwashes
Disclosed herein are mouthwashes comprising a complex of a zinc ion source and an amino acid. Methods of making and using the compositions are also provided.
1. An oral care composition comprising a zinc amino acid halide complex, wherein the zinc amino acid halide complex is a zinc lysine chloride complex having the chemical structure [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + Cl − , in an amount to provide 0.5-2% zinc by weight of the oral care composition, the oral care composition further comprising humectant in an amount of 10-25% by weight, and non-ionic surfactant in an amount of 0.1-1% by weight.
2. The oral care composition of claim 1 , wherein the zinc amino acid halide complex is formed from precursors.
3. The oral care composition of claim 2 , and wherein the precursors are a zinc ion source, an amino acid source, and a halide source.
4. The oral care composition of claim 2 , wherein the halide source can be part of the zinc ion source, the amino acid source, or a halogen acid.
5. The oral care composition of claim 3 , wherein the amino acid source is lysine in free or orally acceptable acid addition salt form.
6. The oral care composition of claim 5 , wherein the zinc ion source and the amino acid source form the complex in situ.
7. The oral care composition of claim 1 , wherein the zinc is solubilized in the formulation, but provides a zinc precipitate upon use and dilution with saliva and/or rinsing.
8. The oral care composition of claim 1 , wherein the zinc amino acid halide complex is in solution of the cationic complex cation (e.g., [Zn(C 6 H 14 N 2 O 2 ) 2 Cl] + and the chloride anion, optionally in mono- or dihydrate form.
9. The oral care composition of claim 1 , further comprising an effective amount of a fluoride ion source.
10. The oral care composition of claim 1 comprising an orally acceptable base comprising ingredients selected from one or more of buffering agents, thickeners, breath fresheners, flavoring, fragrance, coloring, antibacterial agents, whitening agents, agents that interfere with or prevent bacterial attachment, calcium sources, phosphate sources, orally acceptable potassium salts, and anionic polymers.
11. The oral care composition of claim 1 , further comprising cocamidopropyl betaine.
12. The oral care composition of claim 1 , wherein the pH of the composition is from pH 4 to pH 8.
13. The oral care composition of claim 1 , wherein the composition further comprises sweetener, flavorings, and water.
14. The oral care composition of claim 1 , wherein the weight ratio of the zinc amino acid halide to water is from about 1:6 to about 1:1.
15. A method of treating or reducing dental enamel erosion cleaning the teeth, reducing bacterially-generated biofilm and plaque, reducing gingivitis, inhibiting tooth decay and formation of cavities, and/or reducing dentinal hypersensitivity comprising applying the oral care composition according to claim 1 to the teeth.
16. The method of claim 15 further comprising the step of rinsing with sufficient water or aqueous solution to trigger precipitation of zinc oxide from the oral care composition.