Hierarchical siliceous mesosilicalite nanocarrier
A mesosilicalite nanocarrier having a hierarchical silicalite characterized by a molar ratio of aluminum to silica in a range of 1:3000 to 1:1000. The hierarchical silicalite includes mesopores of a hexagonal structure, and micropores of silicalite structure with a microporous volume in the range of 0.05 cc/g to 0.1 cc/g. The nanocarrier has a mesophase content in the range of 30 wt % to 70 wt %, a microphase content in the range of 30 wt % to 70 wt %, and a mean pore diameter in the range of 1.5 nm to 5.5 nm. A method of preparing the stable mesosilicalite nanocarrier with hierarchical micro/mesopores to load an antioxidant or drug for targeted drug delivery is also described.
1. A mesosilicalite nanocarrier comprising:
a hierarchical silicalite having a silica to aluminum molar ratio in a range of 1500:1 to 3000:1, comprising:
a mesophase with mesopores of a hexagonal structure, the mesopores having a volume in a range of 0.5 cc/g to 0.75 cc/g; and
a microphase with micropores of a microporous volume in the range of 0.05 cc/g to 0.1 cc/g;
and 10-50 wt % gallic acid relative to a total weight of the nanocarrier, the gallic acid in an amorphous state and loaded in the mesopores and the micropores of the nanocarrier;
wherein the mesopores have pore diameters between 3.2 nm and 3.7 nm, and the micropores have pore diameters between 2.4 nm and 3.0 nm;
wherein the mesophase content is in the range of 30% to 70% relative to a total weight of the nanocarrier, and the microphase content is in the range of 30% to 70% relative to the total weight of the nanocarrier;
wherein a mean pore diameter of the mesosilicalite nanocarrier is in the range of 3 to 4 nm; and
wherein a total recovery yield for the gallic acid is in the range of 95%-100% at a gallic acid loading rate in the range of 0.1 mmol/g of the nanocarrier to 1.0 mmol/g of the nanocarrier.
2. The mesosilicalite nanocarrier of claim 1 , wherein the mesopores are cylindrically shaped and in an ordered hexagonal structure,
wherein the microphase has micropores with each micropore connected to its eight nearest micropores through pore openings, and
wherein the mesosilicalite nanocarrier has a structure with the mesophase being layered under the microphase.
3. The mesosilicalite nanocarrier of claim 1 , wherein the gallic acid was loaded at a loading rate in the range of 0.1 mmol/g of the nanocarrier to 16 mmol/g of the nanocarrier.