Biocompatible biodegradable intraocular implant system
Generally, an intraocular implant and methods for treating an ocular condition. As to certain embodiments, an intraocular biocompatible biodegradable implant ( 11 ) which can provide a biocompatible biodegradable material in the form of a flexible membrane ( 12 ) containing an active agent ( 24 ) which implanted between an intraocular lens ( 8 ) and the surface of the posterior capsule ( 5 ) of the eye ( 1 )( 4 ) inhibits migration of residual lens epithelial cells after cataract surgery by providing structural or pharmaceutical barriers to reduce posterior capsule ( 5 ) opacification of the eye ( 1 )( 4 ).
1. An intraocular implant, comprising:
a) a biocompatible flexible membrane implantable between a lens and a surface of a posterior capsule of an eye; wherein the biocompatible flexible membrane has a uniform thickness; wherein said biocompatible flexible membrane is biodegradable and comprises a first flexible membrane layer coupled to a second flexible membrane layer; and
b) an aperture element which communicates between opposed sides of said biocompatible flexible membrane to provide a passage opening, said passage opening located in said biocompatible flexible membrane to intraocularly align with a visual axis of said eye upon implantation of said biocompatible flexible membrane between said lens and said surface of said posterior capsule of said eye, thereby providing a line of sight which passes through said passage opening; wherein the aperture element defines a circular passage opening having a diameter in the range of about 1.5 millimeter to about 9 millimeters.
2. The intraocular implant of claim 1 , further comprising at least one active agent dispersed in said biodegradable biocompatible flexible membrane releasable in sufficient amounts to treat an ocular condition.
3. The intraocular implant of claim 1 , wherein said first flexible membrane layer and said second flexible membrane layer comprise different polymeric materials.
4. The intraocular implant of claim 3 , wherein said first flexible membrane layer biodegrades at a different rate than said second flexible membrane layer.
5. The intraocular implant of claim 4 , wherein at least one of said first flexible membrane layer and said second flexible membrane layer include an active agent.
6. The intraocular implant of claim 5 , wherein said first flexible membrane layer and said second flexible membrane layer each contain said active agent, and wherein said active agent contained in said first flexible membrane layer is different than said active agent contained in said second flexible membrane layer.
7. The intraocular implant of claim 1 , wherein said biocompatible biodegradable flexible membrane comprises a first annular zone and a second annular zone.
8. The intraocular implant of claim 7 , wherein said first annular zone biodegrades at a different rate than said second annular zone.
9. The intraocular implant of claim 8 , wherein at least one of said first annular zone and said second annular zone contain an active agent.
10. The intraocular implant of claim 9 , wherein said first annular zone and said second annular zone each contain an active agent, and wherein said active agent contained in said first annular zone is different than said active agent contained in said second annular zone.
11. The intraocular implant of claim 1 , further comprising an outer boundary of said biodegradable biocompatible flexible membrane which defines a generally circular area.
12. The intraocular implant of claim 11 , further comprising a plurality of radial slit elements each originating at said aperture element extending radially outward toward said outer boundary.
13. The intraocular implant of claim 11 , further comprising a plurality of radial slit elements each originating at said outer boundary extending radially inward toward said aperture element.
14. The intraocular implant of claim 11 , further comprising a plurality of radial capillaries which communicate between said outer boundary and said aperture element, said plurality of radial capillaries configured to allow fluid within said eye to circulate between said first side of said intraocular implant and a surface of said localized region inside said eye.
15. The intraocular implant of claim 11 , further comprising a plurality of outer boundary recess elements which periodically interrupt the outer boundary.
16. The intraocular implant of claim 1 , further comprising a patterned surface element coupled to said biodegradable biocompatible flexible membrane, said pattern surface element configured to reduce travel of said intraocular implant within said localized region of said eye.