Methods of treating fungal infections
Antifungal pharmaceutical compositions, dosage forms, and methods of use thereof are disclosed.
1. A method of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7, wherein said BmKn2 and said Kn2-7 peptides comprise combination of D form and L form amino acids.
2. A method of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition comprising one or more peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7, wherein the fungal infection is resistant t one or more conventional antifungal agents.
3. The method of claim 1 or claim 2 wherein the fungal infection is a planktonic or a biofilm fungal infection, or a combination thereof.
4. The method of claim 3 wherein the biofilm fungal infection comprises a pre-formed biofilm.
5. The method of claim 1 wherein the fungal infection is resistant to one or more conventional antifungal agents.
6. The method of claim 1 or claim 2 wherein the infection is a wound infection.
7. The method of claim 1 or claim 2 wherein the pharmaceutical composition is administered alone, or in combination with a therapeutically effective amount of one or more additional pharmaceutically acceptable agents.
8. The method of claim 7 wherein the one or more additional pharmaceutically acceptable agents is selected from the group consisting of an antimicrobial agent, an analgesic, a wound healing agent, a biofilm dispersal agent, and a biofilm inhibitor agent.
9. The method of claim 8 wherein the antimicrobial agent is selected from the group consisting of an antifungal agent, an antibacterial agent, and an antiviral agent.
10. The method of claim 1 or claim 2 wherein the peptide is dKn2-7.
11. The method of claim 1 or claim 2 wherein the fungal infection is caused by Candida.
12. The method of claim 11 wherein the fungal infection is caused by Candida albicans.
13. The method of claim 8 wherein the additional pharmaceutically acceptable agent is a wound healing agent.
14. The method of claim 13 wherein the wound healing agent is an alginate.