Control system

1. A control system controlling at least one blood gas value in blood processed by an oxygenator of an extracorporeal perfusion system, wherein the oxygenator is configured to generate arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, the control system comprising:

a monitoring arrangement to determine a level of the at least one blood gas value in the arterial blood,

a blender having a plurality of gas inlets and a mixing chamber operable to provide the oxygenation gas supply, and

a controller responsive to the monitoring arrangement, the controller configured to control parameters of the oxygenation gas supply to the oxygenator, to adjust at least one of the blood gas values toward a pre-determined level, and wherein the controller comprises a configuration permitting it to alter the composition and a flow rate of the oxygenation gas supplied to the oxygenator,

wherein the controller is configured to simultaneously control the partial pressure of oxygen in the arterial blood and the partial pressure of carbon dioxide in the arterial blood by setting the flow rate of the oxygenation gas supply from the mixing chamber to a level suitable for adjusting the partial pressure of carbon dioxide, and at the set flow rate, setting the fraction of oxygen in the mixing chamber so that the fraction of oxygen in the oxygenation gas supply is at a level suitable for adjusting the partial pressure of oxygen.

2. The control system according to claim 1 , wherein the blood gas values comprise at least one of (a) the partial pressure of oxygen in the arterial blood and (b) the partial pressure of carbon dioxide in the arterial blood.

3. The control system according to claim 1 , wherein the controller is configured to adjust the partial pressure of carbon dioxide in the arterial blood by altering the flow rate of the oxygenation gas supply.

4. The control system according to claim 1 , wherein the controller is configured to adjust the partial pressure of oxygen in the arterial blood by altering the fraction of oxygen in the oxygenation gas supply.

5. The control system according to claim 1 , wherein the controller comprises decision logic to determine a difference between the level of the blood gas value and the pre-determined level, and to determine oxygenation gas supply parameters suitable for reducing the difference.

6. The control system according to claim 5 , wherein the decision logic is configured to reduce the difference by calculating an offset value representing a change in oxygenation gas supply parameters suitable for reducing the difference.

7. The control system according to claim 5 , wherein the pre-determined level is a pre-determined partial pressure of carbon dioxide in the arterial blood, and wherein the oxygenation gas supply parameters comprise a flow rate suitable for reducing the difference.

8. The control system according to claim 5 , wherein the pre-determined level is a pre-determined partial pressure of oxygen in the arterial blood, and wherein the oxygenation gas supply parameters comprise a fraction of oxygen suitable for reducing the difference.

9. The control system according to claim 1 , wherein the controller is configured to simultaneously control a plurality of parameters of the oxygenation gas supply to the oxygenator, to simultaneously adjust levels of a plurality of blood gas values.

10. A method of controlling at least one blood gas value in blood processed by an oxygenator of an extracorporeal perfusion system, wherein the oxygenator is configured to generate arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, the method comprising the steps of:

determining a level of each of the at least one blood gas value in the arterial blood,

delivering the oxygenation gas supply from a mixing chamber, and

simultaneously controlling, in response to the level, partial pressure of oxygen in the arterial blood and partial pressure of carbon dioxide in the arterial blood by setting a flow rate of the oxygenation gas supply from the mixing chamber to the oxygenator to a level suitable for adjusting the partial pressure of carbon dioxide, and at the set flow rate, setting the fraction of oxygen in the mixing chamber to a level suitable for adjusting the partial pressure of oxygen.

11. The method according to claim 10 , wherein determining a level of at least one blood gas value comprises monitoring at least one of (a) the partial pressure of oxygen in the arterial blood and (b) the partial pressure of carbon dioxide in the arterial blood.

12. The method according to claim 10 , further comprising adjusting the partial pressure of carbon dioxide in the arterial blood by altering the flow rate of the oxygenation gas supply.

13. The method according to claim 10 , further comprising adjusting the partial pressure of oxygen in the arterial blood by altering the fraction of oxygen in the oxygenation gas supply.

14. The method according to claim 10 , further comprising

determining a difference between the level of the blood gas value and the pre-determined level, and

determining oxygenation gas supply parameters suitable for reducing the difference.

15. The method according to claim 14 , further comprising

calculating an offset value representing a change in oxygenation gas supply parameters suitable for reducing the difference, and

determining the oxygenation gas supply parameters on the basis of the offset value.

16. The method according to claim 14 , further comprising

determining the difference between the level of the partial pressure of carbon dioxide in the arterial blood and the pre-determined level of the partial pressure of carbon dioxide in the arterial blood, and

determining an oxygenation gas flow rate suitable for reducing the difference.

17. The method according to claim 14 , further comprising

determining the difference between the level of the partial pressure of oxygen in the arterial blood and the pre-determined level of the partial pressure of oxygen in the arterial blood, and

determining an oxygenation gas oxygen fraction suitable for reducing the difference.

18. The method according to claim 10 , comprising simultaneously controlling a plurality of parameters of the oxygenation gas supply to the oxygenator, to simultaneously effect an adjustment of levels of a plurality of blood gas values.