Method and system for ECG based cardiac ischemia detection

1. An acute ischemia detection device comprising:

a 12-lead electrocardiograph (ECG) device;

an electronic data processing device programmed to perform operations including:

applying the 12-lead ECG device to vessel-specific lead (VSL) transforms to 12-lead ECG data acquired by the 12-lead ECG device to generate VSL lead data,

determining ST values for the VSL lead data, and

deciding whether the 12-lead ECG data acquired by the 12-lead ECG device indicates acute ischemia by comparing each ST value for the VSL lead data with respective VSL lead ST thresholds; and

a display component configured to display an acute ischemia alarm or warning after the decision is the 12-lead ECG data acquired by the 12-lead ECG device indicates the acute ischemia, wherein the deciding is not based on baseline 12 lead ECG data that is known not to indicate the acute ischemia.

2. The acute ischemia detection device of claim 1 , wherein the applying includes:

choosing the 12-lead ECG to VSL transforms for either a standard 12-lead ECG electrode placement or a Mason-Likar 12-lead ECG electrode placement based on the 12-lead ECG electrode placement used to acquire the 12-lead ECG data.

3. The acute ischemia detection device of claim 1 , wherein the deciding includes:

choosing the VSL lead ST thresholds based on a gender of a subject for which the 12-lead ECG data is acquired.

4. The acute ischemia detection device of claim 1 , wherein the applying includes:

applying a 12-lead ECG to left anterior descending (LAD) artery transform to 12-lead ECG data acquired by the 12-lead ECG device to generate LAD lead data;

applying a 12-lead ECG to left circumflex (LCX) artery transform to 12-lead ECG data acquired by the 12-lead ECG device to generate LCX lead data; and

applying a 12-lead ECG to left right coronary artery (RCA) transform to 12-lead ECG data acquired by the 12-lead ECG device to generate RCA lead data.

5. The acute ischemia detection device of claim 1 , wherein the display component is further configured to display the generated VSL lead data as VSL lead traces.

6. The acute ischemia detection device of claim 1 , further comprising:

an electronic data processing device programmed to perform offline operations of:

generating an ST map for each VSL based on at least one body surface potentials mapping (BSPM) dataset acquired with a coronary artery corresponding to the VSL occluded;

identifying locations for each VSL at which the ST map shows a maximum ST elevation and a maximum ST depression; and

determining the 12-lead ECG to VSL transform using the at least one BSPM dataset and the identified locations for each VSL.

7. The acute ischemia detection device of claim 6 , wherein the electronic data processing device is programmed to perform further offline operations of:

optimizing the VSL lead ST thresholds to optimally decide the acute ischemia for 12-lead ECG training data labeled as to whether the 12-lead ECG training data are for a subject with the acute ischemia or without the acute ischemia.

8. An acute ischemia detection method comprising:

acquiring 12-lead electrocardiograph (ECG) data for a subject;

applying the 12-lead ECG data to vessel-specific lead (VSL) transforms to the 12-lead ECG data to generate VSL lead data for the subject;

determining ST values for the VSL lead data;

deciding whether the subject has acute ischemia by comparing each ST value for the VSL lead data with respective VSL lead ST thresholds;

issuing an acute ischemia alarm or warning after the decision is that the subject has the acute ischemia wherein the deciding is not based on baseline 12 lead ECG data that is known not to indicate the acute ischemia.