Composition for a wound dressing
The present invention relates to a composition that can be used as or as part of a wound dressing and to wound dressings comprising the same. More specifically, the present invention relates to a composition that disrupts and kills bacteria within a biofilm and also prevents biofilm formation. The composition comprises a first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and combinations thereof; at least one triprotic acid and at least one solubilising acid.
1. A composition comprising a fibrous first component selected from the group consisting of chitosan, chitin, derivatives of chitosan, derivatives of chitin, and any combination thereof; at least one triprotic acid and at least one solubilizing acid, wherein the triprotic acid is present in an amount of at least 25% of the first component.
2. The composition as claimed in claim 1 , wherein the first component is non-antimicrobial.
3. The composition as claimed in claim 1 , wherein the ratio of the first component to the at least one triprotic acid is at least 2:1; and/or wherein the ratio of the at least one triprotic acid to the at least one solubilising acid is at least 1:1.
4. The composition as claimed in claim 1 , wherein the first component is chitosan; and/or wherein the triprotic acid is citric acid.
5. The composition as claimed in claim 1 , wherein the first component has a degree of de-acetylation greater than 70%; and/or wherein the first component has a viscosity greater than 150 cps in 1% acetic acid solution.
6. The composition as claimed in claim 1 , wherein the fibrous first component are nonwoven.
7. The composition as claimed in claim 1 , wherein the triprotic acid is present in an amount of around 25 to 60% of the first component.
8. The composition as claimed in claim 1 , wherein the composition is in the form of granules, flakes, powder, nonwoven textile or knitted textile.
9. The composition as claimed in claim 1 , wherein the solubilising acid is a monoprotic acid.
10. The composition as claimed in claim 9 , wherein the monoprotic acid is selected from the group consisting of lactic acid, formic acid, acetic acid, hydrochloric acid, and mixtures thereof.
11. The composition as claimed in claim 1 , wherein the triprotic acid and the solubilising acid are coated onto the first component.
12. The composition as claimed in claim 1 , wherein the solubilising acid is present in an amount of from 2-50% of the first component, and optionally wherein the solubilising acid is present in an amount of from 15-30% of the first component.
13. The composition as claimed in claim 1 , wherein the triprotic acid and/or the solubilising acid is coated onto a carrier material.
14. The composition as claimed in claim 1 , further comprising an additional component selected from the group consisting of antimicrobial agents; pharmaceutical agents; chelating agents; wetting agents; growth factors; cytokines; agents which absorb agents which delay healing; calcium; vitamin K; fibrinogen; thrombin; factor VII; factor VIII; clays; oxidised regenerated cellulose; gelatin; and collagen.