Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films

1. A water continuous dispersion of nanoparticles comprising:

ibuprofen;

one or more high HLB surfactants;

one or more low HLB surfactants each independently comprising a saccharide residue;

one or more oils;

water;

wherein a concentration of the ibuprofen in the water continuous dispersion of nanoparticles is greater than about 2 weight percent (%), and

wherein the ibuprofen does not form crystals from the water continuous dispersion of nanoparticles for greater than about 14 days at a temperature from about 2° C. to about 4° C.

2. The water continuous dispersion of nanoparticles of claim 1 , wherein the one or more high HLB surfactants each independently comprise laureth 23, laureth-30, ceteareth-20, ceteareth-30, ethoxylated castor oil, or a combination thereof.

3. The water continuous dispersion of nanoparticles of claim 1 , wherein the one or more low HLB surfactants each independently comprising a saccharide residue comprise sorbitan oleate, sorbitan stearate, or a combination thereof.

4. The water continuous dispersion of nanoparticles of claim 1 , wherein the one or more oils each independently comprise isopropyl myristate, mineral oil, fractionated coconut oil, medium chain triglyceride oil, or a combination thereof.

5. The water continuous dispersion of nanoparticles of claim 1 , further comprising one or more hydrophilic non-amphipathic polysaccharide compounds.

6. The water continuous dispersion of nanoparticles of claim 5 , wherein the one or more hydrophilic non-amphipathic polysaccharide compounds comprise maltodextrin.

7. The water continuous dispersion of nanoparticles of claim 1 , further comprising one or more medium HLB surfactants.

8. The water continuous dispersion of nanoparticles of claim 7 , wherein the one or more medium HLB surfactants comprise polysorbate 21.

9. A water continuous dispersion of nanoparticles comprising:

ibuprofen;

one or more high HLB surfactants each independently comprising laureth 23, laureth-30, ceteareth-20, ceteareth-30, ethoxylated castor oil, or a combination thereof;

one or more low HLB surfactants each independently comprising a saccharide residue comprising sorbitan oleate, sorbitan stearate, or a combination thereof;

one or more oils each independently comprising isopropyl myristate, mineral oil, fractionated coconut oil, medium chain triglyceride oil, or a combination thereof;

water;

wherein a concentration of the ibuprofen in the water continuous dispersion of nanoparticles is greater than about 2 weight percent (%), and

wherein the ibuprofen does not form crystals from the water continuous dispersion of nanoparticles for greater than about 14 days at a temperature from about 2° C. to about 4° C.

10. The water continuous dispersion of nanoparticles of claim 9 , further comprising one or more hydrophilic non-amphipathic polysaccharide compounds comprising maltodextrin.

11. The water continuous dispersion of nanoparticles of claim 9 , further comprising one or more medium HLB surfactants comprising polysorbate 21.

12. A water continuous dispersion of nanoparticles comprising:

ibuprofen;

one or more high HLB surfactants each independently comprising laureth 23, laureth-30, ceteareth-20, ceteareth-30, ethoxylated castor oil, or a combination thereof;

one or more low HLB surfactants each independently comprising a saccharide residue comprising sorbitan oleate, sorbitan stearate, lecithin, or a combination thereof;

one or more oils each independently comprising isopropyl myristate, mineral oil, fractionated coconut oil, medium chain triglyceride oil, or a combination thereof;

one or more hydrophilic non-amphipathic polysaccharide compounds comprising maltodextrin;

one or more medium HLB surfactants;

water;

wherein a concentration of the ibuprofen in the water continuous dispersion of nanoparticles is greater than about 2 weight percent (%), and

wherein the ibuprofen does not form crystals from the water continuous dispersion of nanoparticles for greater than about 14 days at a temperature from about 2° C. to about 4° C.

13. The water continuous dispersion of nanoparticles of claim 12 , wherein the one or more medium HLB surfactants comprise polysorbate 21.