Methods of treating RSV infections
Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.
1. A method for treating a respiratory syncytial virus (RSV) infection in a young child, the method comprising the following step:
administering to a subject a polypeptide that binds a protein of human RSV (hRSV), wherein the protein is glycoprotein F (F-protein), wherein the polypeptide has the amino acid sequence of SEQ ID NO: 71, wherein the polypeptide is administered by inhalation with a vibrating mesh nebulizer at a deposited dose of 0.020-0.040 mg/kg daily and wherein the subject is a young child.
2. The method of claim 1 , wherein the polypeptide is administered at an inhaled dose of 0.20-0.40 mg/kg daily.
3. The method of claim 1 , wherein the polypeptide is administered at a nominal dose of 1.00-2.00 mg/kg daily.
4. The method of claim 1 , wherein the step of administering is performed daily for 2 to 5 consecutive days.
5. The method of claim 1 , wherein the step of administering is performed daily for 3 consecutive days.
6. The method of claim 1 , wherein the young child is less than 2 years old.
7. The method of claim 1 , wherein the step of administering is performed by use of a nebulizer.
8. The method of claim 1 , wherein the polypeptide is the only therapeutic agent administered to the young child.
9. The method of claim 1 , further comprising the step of administering to the young child an additional therapeutic agent.
10. The method of claim 9 , wherein the additional therapeutic agent is a bronchodilator.