Optical detection of air bubbles in either saline or blood or a mixture of both
Embodiments of the disclosure provide a system and method for detection of a transient air bubble in an arterial blood flow path during dialysis (e.g., hemodialysis). The system uses measurements from an optical sensor to remove one or more effects of common factors affecting the absorbance of the light incident on the arterial tubing. These factors include color of medium within the arterial tubing, tubing color, angle of illumination, and temperature of the optical detector. A variance of the measurements from the optical sensor are used to determine whether an air bubble is present.
1. A method for detecting air bubbles in a blood flow path of a dialysis system, the method comprising:
setting, by a processor of the dialysis system, initial intensities of light for a first light emitter of the dialysis system corresponding to a first wavelength and for a second light emitter of the dialysis system corresponding to a second wavelength;
determining, by the processor, received intensities of light for a first photosensor of the dialysis system corresponding to the first wavelength and for a second photosensor of the dialysis system corresponding to the second wavelength, wherein the light received at the first and second photosensors originated at the first and second light emitters and traversed the blood flow path of the dialysis system;
determining, by the processor, a first light absorption value based on the difference between the initial intensity of light at the first wavelength and the received intensity of light at the first wavelength;
determining, by the processor, a second light absorption value based on the difference between the initial intensity of light at the second wavelength and the received intensity of light at the second wavelength;
determining, by the processor, a normalized ratio between the first light absorption value and the second light absorption value to remove common mode factors affecting absorbance of light;
comparing, by the processor, the determined normalized ratio to a previous normalized ratio corresponding to a previous time to determine an amount of change;
detecting, by the processor, that an air bubble is present in the blood flow path in response to the amount of change being greater than a threshold amount; and
executing, by the processor, a responsive operation in response to detecting that an air bubble is present in the blood flow path.
2. The method according to claim 1 , wherein the responsive operation comprises:
stopping a pumping operation in response to detecting that an air bubble is present in the blood flow path.
3. The method according to claim 1 , wherein the responsive operation comprises:
generating an alarm in response to detecting that an air bubble is present in the blood flow path.
4. The method according to claim 1 , wherein setting the initial intensities of light comprises:
controlling electrical currents provided to the first and second light emitters to be at predetermined current levels.
5. The method according to claim 1 , wherein determining the received intensities of light comprises:
measuring electrical currents generated by the first and second photosensors.
6. The method according to claim 1 , wherein the first wavelength is a red light wavelength and the second wavelength is an infrared wavelength.
7. The method according to claim 1 , wherein a sampling rate for detecting whether an air bubble is present in the blood flow path is within the range of 100 Hz to 1000 Hz.
8. A dialysis system, comprising:
a blood flow path;
a first light emitter configured to generate light at a first wavelength;
a second light emitter configured to generate light at a second wavelength;
a first photosensor configured to detect light at the first wavelength originating from the first light emitter and after traversing the blood flow path;
a second photosensor configured to detect light at the second wavelength originating from the second light emitter and after traversing the blood flow path; and
a processor, configured to:
set initial intensities of light for the first and second light emitters;
determine received intensities of light for the first and second photosensors;
determine a first light absorption value based on the difference between the initial intensity of light at the first wavelength and the received intensity of light at the first wavelength;
determine a second light absorption value based on the difference between the initial intensity of light at the second wavelength and the received intensity of light at the second wavelength;
determine a normalized ratio between the first light absorption value and the second light absorption value to remove common mode factors affecting absorbance of light;
compare the determined normalized ratio to a previous normalized ratio corresponding to a previous time to determine an amount of change;
detect that an air bubble is present in the blood flow path in response to the amount of change being greater than a threshold amount; and
execute a responsive operation in response to detecting that an air bubble is present in the blood flow path.
9. The system according to claim 8 , wherein the responsive operation comprises:
stopping a pumping operation in response to detecting that an air bubble is present in the blood flow path.
10. The system according to claim 8 , wherein the responsive operation comprises:
generating an alarm in response to detecting that an air bubble is present in the blood flow path.
11. The system according to claim 8 , further comprising:
at least one driver configured to provide electrical current to the first light emitter and to the second light emitter;
wherein setting the initial intensities of light comprises: controlling electrical currents provided to the first and second light emitters to be at predetermined current levels.
12. The system according to claim 8 , wherein determining the received intensities of light comprises:
measuring electrical currents generated by the first and second photosensors.
13. The system according to claim 8 , wherein the first wavelength is a red light wavelength and the second wavelength is an infrared wavelength.
14. The system according to claim 8 , wherein the processor is configured to utilize a sampling rate within the range of 100 Hz to 1000 Hz for determining whether an air bubble is present in the blood flow path.
15. A non-transitory computer-readable medium of a dialysis system having processor-executable instructions stored thereon for detecting air bubbles in a blood flow path of the dialysis system, the processor-executable instructions, when executed, facilitating performance of the following:
setting initial intensities of light for a first light emitter of the dialysis system corresponding to a first wavelength and for a second light emitter of the dialysis system corresponding to a second wavelength;
determining received intensities of light for a first photosensor of the dialysis system corresponding to the first wavelength and for a second photosensor of the dialysis system corresponding to the second wavelength, wherein the light received at the first and second photosensors originated at the first and second light emitters and traversed the blood flow path of the dialysis system;
determining a first light absorption value based on the difference between the initial intensity of light at the first wavelength and the received intensity of light at the first wavelength;
determining a second light absorption value based on the difference between the initial intensity of light at the second wavelength and the received intensity of light at the second wavelength;
determining a normalized ratio between the first light absorption value and the second light absorption value to remove common mode factors affecting absorbance of light;
comparing the determined normalized ratio to a previous normalized ratio corresponding to a previous time to determine an amount of change;
detecting that an air bubble is present in the blood flow path in response to the amount of change being greater than a threshold amount; and
executing a responsive operation in response to detecting that an air bubble is present in the blood flow path.
16. The non-transitory computer-readable medium according to claim 15 , wherein the responsive operation comprises:
stopping a pumping operation in response to detecting that an air bubble is present in the blood flow path.
17. The non-transitory computer readable medium according to claim 15 , wherein the responsive operation comprises:
generating an alarm in response to detecting that an air bubble is present in the blood flow path.
18. The non-transitory computer readable medium according to claim 15 , wherein setting the initial intensities of light comprises:
controlling electrical currents provided to the first and second light emitters to be at predetermined current levels.
19. The non-transitory computer readable medium according to claim 15 , wherein determining the received intensities of light comprises:
measuring electrical currents generated by the first and second photosensors.
20. The non-transitory computer readable medium according to claim 15 , wherein the first wavelength is a red light wavelength and the second wavelength is an infrared wavelength.