Compounds and compositions for the treatment of parasitic diseases
The present invention provides compounds of Formula A: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as leishmaniasis, human African trypanosomiasis and Chagas disease.
1. A method for treating leishmaniasis, comprising administering to a subject in need thereof a therapeutically effective amount of N-(4-fluoro-3-(6-(3-methylpyridin-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)phenyl)-2,4-dimethyloxazole-5-carboxamide, or a pharmaceutically acceptable salt thereof; and optionally in combination with a second agent.
2. The method of claim 1 , wherein said leishmaniasis is caused by the parasite Leishmania donovani, Leishmania infantum, Leishmania braziliensis, Leishmania panamensis, Leishmania guayanensis, Leishmania amazonensis, Leishmania mexicana, Leishmania tropica , or Leishmania major.
3. The method of claim 1 , wherein said leishmaniasis is visceral leishmaniasis.
4. The method of claim 1 , wherein said leishmaniasis is cutaneous leishmaniasis.
5. The method of claim 1 , wherein said second agent is stibogluconate, meglumine antimoniate, amphotericin, miltefosine or paromomycin.