Multicomponent meso thread containing hyaluronic acid and method for producing same (variants)
The group of inventions relates to the field of aesthetic, plastic and reconstructive cosmetology/medicine, and more particularly to meso threads used for remedying aesthetic and age-related changes to the skin, and to methods for producing such threads. Proposed is a multicomponent meso thread consisting of a core and a shell. The core is realized in the form of a fibroin thread, and the shell contains hyaluronic acid or a salt thereof or a polyelectrolyte complex of hyaluronic acid or a salt thereof and chitosan or a salt thereof. Also proposed are a variant of the thread having a plastifying agent in the shell, and methods for producing the proposed meso threads.
1. A multicomponent mesothread, comprising:
a core and a coating,
wherein the core is a fibroin thread,
wherein the coating comprises a polyelectrolyte complex of hyaluronic acid or its salt with chitosan or its salt, and
wherein the coating has a thickness of 18-105 micrometers.
2. The multicomponent mesothread according to claim 1 , wherein the hyaluronic acid salt comprises at least one of tetraalkylammonium, lithium, sodium, potassium, calcium, magnesium, barium, zinc, aluminum, copper, aurate, and hyaluronic acid hydrosalt.
3. The multicomponent mesothread according to claim 1 , wherein the chitosan comprises a chitosan with a deacetylation degree over 50%, and the chitosan salt comprises chitosan acetate, chitosan chloride, or chitosan lactate.
4. The multicomponent mesothread according to claim 1 , wherein the core and/or coating additionally contains a plastifying agent.
5. The multicomponent mesothread according to claim 4 , wherein the plastifying agent comprises polyvinyl alcohol.
6. The multicomponent mesothread according to claim 1 , wherein the coating additionally contains an antiinfection agent and/or an antiseptic and/or an antibiotic.
7. The multicomponent mesothread according to claim 1 , wherein the coating additionally contains an antiinfection agent, wherein the antiinfection agent comprises beta-(5-nitrofuryl-2)-acrolein.
8. The multicomponent mesothread according to claim 1 , wherein the coating additionally comprises an antiseptic agent, wherein the antiseptic agent comprises benzyldimethyl [3-(myristoylamino)propyl] ammonium chloride monohydrate.
9. The multicomponent mesothread of claim 1 , wherein the polyelectrolyte complex comprises polycation-polyanion layers, each one of said layers being an electrostatically sealed film.