Solid forms of cannabidiol and uses thereof
Disclosed herein are cocrystals of cannabidiol and a coformer containing 5-6 membered rings comprised of carbon and nitrogen atoms, wherein the 5-6 membered rings can be unsaturated or saturated and the rings contain 1 to 2 nitrogen atoms. Cocrystals of cannabidiol and a coformer selected from L-proline, D-proline, tetramethylpyrazine, and 4,4′-dipyridyl are also disclosed herein.
1. A solid form comprising cannabidiol and the coformer tetramethylpyrazine, wherein the solid form has an x-ray diffraction pattern comprising one or more peaks at about 9.1, 14.6, 18.3, and 19.6 degrees 2θ±0.2.
2. The solid form of claim 1 having an x-ray powder diffraction pattern substantially similar to FIG. 12 .
3. The solid form of claim 1 , wherein the molar ratio of cannabidiol to tetramethylpyrazine is about 1:1.
4. The solid form of claim 1 , which is crystalline.
5. The solid form of claim 1 , which is a cocrystal.
6. The solid form of claim 1 having a DSC thermogram with a peak onset of approximately 89.9° C. or a peak maximum at about 92.8° C.
7. The solid form of claim 6 having a DSC thermogram which is substantially similar to the DSC thermogram of FIG. 13 .
8. A pharmaceutical composition comprising the solid form of claim 1 .
9. The pharmaceutical composition of claim 8 , further comprising a pharmaceutically acceptable excipient or carrier.