IP Library › Granted Patent US 10,611,739
Granted Patent B2
US 10,611,739 · App. 16/326,239 · Granted Apr 7, 2020

Process for preparation of lactone derivatives and intermediates thereof

Inventors: Ping Chen (Shanghai, CN); Shaoping Peng (Shanghai, CN); Yinqiang Li (Shanghai, CN); Dafeng Li (Shanghai, CN); Xuejun Dong (Shanghai, CN)
Assignee: PHARMARESOURCES (SHANGHAI) CO., LTD.
C07D263/26C07D307/33Y02P20/55
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,611,739
App. No.
16/326,239
Granted
Apr 7, 2020
Kind
B2
Abstract

A novel process for the preparation of lactone derivatives, and intermediates thereof is described. The lactone derivatives are important precursors for the synthesis of anti-hepatitis C virus agents, including sofosbuvir.

Claims (5)

1. A compound of formula (IV),

wherein X is a leaving group selected from Cl, Br, I, and a sulfonate of formula R—SO 3 —; wherein R is methyl, trifluoromethyl, ethyl, phenyl, p-methyl-phenyl, m-methyl-phenyl, o-methyl-phenyl, or naphthalenyl; and

wherein R 4 is OH, R 5 is fluorine, and R 6 is methyl.

2. The compound of claim 1 , wherein X is Cl, Br, I, mesylate, or tosylate.

3. The compound of claim 1 selected from:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 11, 2019
From: CHEN, PING; PENG, SHAOPING; LI, YINQIANG; LI, DAFENG; DONG, XUEJUN
To: PHARMARESOURCES (SHANGHAI) CO., LTD.
Reel/Frame 048555/0764 →
Continuity (1)
Related Publication 20190210981A1 · Jul 11, 2019