Crystalline form of chemical compound, and preparation method, composition, and application thereof

1. A crystalline form of a compound of formula (A):

wherein the crystalline form comprises one or more chosen from a crystalline form I, a crystalline form II, a crystalline form III, or a crystalline form IV,

wherein an X-ray powder diffraction pattern of the crystalline form I comprises characteristic peaks at diffraction angles (2-Theta) of 5.3±0.2°, and 8.6±0.2°,

an X-ray powder diffraction pattern of the crystalline form II comprises characteristic peaks at diffraction angles (2-Theta) of 4.7±0.2°,

an X-ray powder diffraction pattern of the crystalline form III comprises characteristic peaks at diffraction angles (2-Theta) of 5.2±0.2°and 8.0±0.2°, and

an X-ray powder diffraction pattern of the crystalline form IV comprises characteristic peaks at diffraction angles (2-Theta) of 7.4±0.2°, 14.7±0.2°, and 16.0±0.2°.

2. The crystalline form according to claim 1 , wherein a DSC spectrum of the crystalline form I shows a melting temperature at 184±5° C., a DSC spectrum of the crystalline form II shows a melting temperature at 145±5° C., a DSC spectrum of the crystalline form III shows a melting temperature at 187±5° C., and a DSC spectrum of the crystalline form IV shows a melting temperature at 145±5° C.

3. A preparation method of the crystalline form according to claim 1 , wherein the crystalline form I is prepared by:

(1) adding a solvent to the compound of formula (A) to obtain a suspension, and then stirring at room temperature for 0.5 to 3 days to obtain the crystalline form I, wherein the solvent is one or more chosen from a mixture of ethanol and isopropyl ether, a mixture of ethanol and n-heptane, a mixture of isopropanol and n-heptane, or a mixture of tetrahydrofuran and n-heptane;

(2) dissolving the compound of formula (A) into a good solvent to obtain a clear solution, and adding an anti-solvent while stirring to obtain the crystalline form I, wherein the good solvent is one or more chosen from methanol, ethanol, or n-butanol, and the anti-solvent is one or more chosen from isopropyl ether, methyl tert-butyl ether, or methyl cyclohexane;

(3) dissolving the compound of formula (A) in a solvent under heating to a temperature at 40° C. to 90° C. to obtain a clear solution, and cooling the solution to obtain the crystalline form I, wherein the solvent is chosen from a mixture of ethanol and isopropyl ether, a mixture of ethanol and ethyl acetate, a mixture of ethanol and methyl tert-butyl ether, a mixture of ethanol and n-heptane, a mixture of ethanol and methylcyclohexane, or a mixture of n-butanol and n-heptane;

(4) placing the compound of formula (A) in a solvent atmosphere of ethanol for 1-3 days to obtain the crystalline form I; or

(5) adding the crystalline form III and/or the crystalline form IV of the compound of formula (A) into a solvent to form a suspension, stirring and drying to obtain the crystalline form I, wherein the solvent is an ester solvent chosen from ethyl acetate, isopropyl acetate, or a mixture thereof.

4. A preparation method of the crystalline form according to claim 1 , wherein the crystalline form II is prepared by:

(1) dissolving the compound of formula (A) in a solvent to obtain a clear solution, evaporating the solution to dryness at room temperature to give the crystalline form II, wherein the solvent is chosen from a mixture of ethanol and ethyl acetate, a mixture of acetone and ethyl acetate, a mixture of acetone and isopropyl ether, or a mixture of acetone and n-heptane;

(2) adding the compound of formula (A) to a solvent to obtain a clear solution, a saturated solution, a supersaturated solution, or a suspension, and stirring at room temperature for 10 minutes to 5 days to obtain the crystalline form II, wherein the solvent is chosen from isopropanol, sec-butanol, ethyl acetate, toluene, isopropyl acetate, a mixture of ethanol and ethyl acetate, a mixture of ethanol and isopropyl acetate, a mixture of ethanol and toluene, a mixture of acetone and n-heptane, or a mixture of 1,4-dioxane and n-heptane;

(3) dissolving the compound of formula (A) in a good solvent to obtain a clear solution, and adding an anti-solvent under stirring to obtain the crystalline form II, wherein the good solvent is chosen from methyl ethyl ketone, dimethyl sulfoxide, or 1,4-dioxane, and the anti-solvent is chosen from n-heptane, isopropyl ether, or isopropyl acetate;

(4) dissolving the compound of formula (A) in a solvent under heating to a temperature of 40° C. to 90° C. to obtain a clear solution, and cooling the solution to obtain the crystalline form II, wherein the solvent is chosen from sec-butanol, nitromethane, acetone, or tetrahydrofuran;

(5) placing a saturated ethanol solution of the compound of the formula (A) in a solvent atmosphere of isopropyl ether or isopropyl acetate until the crystalline form II precipitates from the saturated ethanol solution; or

(6) placing the compound of formula (A) in a solvent atmosphere of toluene, isopropanol, tetrahydrofuran, or ethyl acetate for 1-3 days to obtain the crystalline form II.

5. A preparation method of the crystalline form according to claim 1 , wherein the crystalline form III is prepared by:

(1) adding tetrahydrofuran to the compound of the formula (A) to obtain a suspension and stirring the suspension to at room temperature for 12 hours to 5 days obtain the crystalline form III; or

(2) placing a saturated tetrahydrofuran solution of the compound of formula (A) in a solvent atmosphere of isopropyl ether until the crystalline form III precipitates from the saturated solution.

6. A preparation method of the crystalline form according to claim 1 , wherein the crystalline form IV is prepared by dissolving the compound of formula (A) in n-butanol to give a clear solution, and adding n-heptane under stirring to obtain the crystalline form IV.

7. A composition comprising the crystalline form I and the crystalline form II according to claim 1 , wherein a weight ratio of the crystalline form I to the crystalline form II is from 1:99 to 99:1.

8. A preparation method of the composition according to claim 7 , comprising:

(1) adding isopropyl acetate to the crystalline form II to obtain a suspension, and stirring at 50° C. to 90° C. for 3 hours to 3 days to obtain a mixture of the crystalline form I and the crystalline form II;

(2) pulverizing and sieving a wet product of the crystalline form II followed by vacuum drying at 40° C. to 60° C. for 3 hours to 3 days;

(3) vacuum drying a wet product of the crystalline form II at 40° C. to 60° C. for 3 hours to 3 days followed by micronizing; or

(4) adding a solvent to the crystalline form II to obtain a suspension, stirring the suspension at room temperature for 3 hours to 3 days to obtain a mixture of the crystalline form I and the crystalline form II, wherein the solvent is chosen from methyl tert-butyl ether or a mixture of ethanol and methylcyclohexane.

9. A pharmaceutical composition comprising a therapeutically effective amount of one, two, or more of the crystalline forms according to claim 1 and a pharmaceutically acceptable carrier; or a therapeutically effective amount of the composition according to claim 7 and a pharmaceutically acceptable carrier.

10. A method for prevention and/or treatment of hypertension, chronic heart failure, diabetic nephropathy, comprising:

preparing an angiotensin II receptor antagonist from a composition comprising one or more chosen from the crystalline forms I, II, III, IV, or a mixture thereof according to claim 1 ; and

administering the angiotensin II receptor antagonist or a medication comprising thereof to a subject in need thereof.

11. The preparation method of the crystalline form according to claim 2 , wherein the crystalline form I is prepared by:

(1) adding a solvent to the compound of formula (A) to obtain a suspension, and then stirring at room temperature for 0.5 to 3 days to obtain the crystalline form I, wherein the solvent is one or more chosen from a mixture of ethanol and isopropyl ether, a mixture of ethanol and n-heptane, a mixture of isopropanol and n-heptane, or a mixture of tetrahydrofuran and n-heptane;

(2) dissolving the compound of formula (A) into a good solvent to obtain a clear solution, and adding an anti-solvent while stirring to obtain the crystalline form I, wherein the good solvent is one or more chosen from methanol, ethanol, or n-butanol, and the anti-solvent is one or more chosen from isopropyl ether, methyl tert-butyl ether, or methyl cyclohexane;

(3) dissolving the compound of formula (A) in a solvent under heating to a temperature at 40° C. to 90° C. to obtain a clear solution, and cooling the solution to obtain the crystalline form I, wherein the solvent is chosen from a mixture of ethanol and isopropyl ether, a mixture of ethanol and ethyl acetate, a mixture of ethanol and methyl tert-butyl ether, a mixture of ethanol and n-heptane, a mixture of ethanol and methylcyclohexane, or a mixture of n-butanol and n-heptane;

(4) placing the compound of formula (A) in a solvent atmosphere of ethanol for 1-3 days to obtain the crystalline form I; or

(5) adding the crystalline form III and/or the crystalline form IV of the compound of formula (A) into a solvent to form a suspension, stirring and drying to obtain the crystalline form I, wherein the solvent is an ester solvent chosen from ethyl acetate, isopropyl acetate, or a mixture thereof.

12. The preparation method of the crystalline form according to claim 2 , wherein the crystalline form II is prepared by:

(1) dissolving the compound of formula (A) in a solvent to obtain a clear solution, evaporating the solution to dryness at room temperature to give the crystalline form II, wherein the solvent is chosen from a mixture of ethanol and ethyl acetate, a mixture of acetone and ethyl acetate, a mixture of acetone and isopropyl ether, or a mixture of acetone and n-heptane;

(2) adding the compound of formula (A) to a solvent to obtain a clear solution, a saturated solution, a supersaturated solution, or a suspension, and stirring at room temperature for 10 minutes to 5 days to obtain the crystalline form II, wherein the solvent is chosen from isopropanol, sec-butanol, ethyl acetate, toluene, isopropyl acetate, a mixture of ethanol and ethyl acetate, a mixture of ethanol and isopropyl acetate, a mixture of ethanol and toluene, a mixture of acetone and n-heptane, or a mixture of 1,4-dioxane and n-heptane;

(3) dissolving the compound of formula (A) in a good solvent to obtain a clear solution, and adding an anti-solvent under stirring to obtain the crystalline form II, wherein the good solvent is chosen from methyl ethyl ketone, dimethyl sulfoxide, or 1,4-dioxane, and the anti-solvent is chosen from n-heptane, isopropyl ether, or isopropyl acetate;

(4) dissolving the compound of formula (A) in a solvent under heating to a temperature of 40° C. to 90° C. to obtain a clear solution, and cooling the solution to obtain the crystalline form II, wherein the solvent is chosen from sec-butanol, nitromethane, acetone, or tetrahydrofuran;

(5) placing a saturated ethanol solution of the compound of the formula (A) in a solvent atmosphere of isopropyl ether or isopropyl acetate until the crystalline form II precipitates from the saturated ethanol solution; or

(6) placing the compound of formula (A) in a solvent atmosphere of toluene, isopropanol, tetrahydrofuran, or ethyl acetate for 1-3 days to obtain the crystalline form II.

13. The preparation method of the crystalline form according to claim 2 , wherein the crystalline form III is prepared by:

(1) adding tetrahydrofuran to the compound of the formula (A) to obtain a suspension and stirring the suspension at room temperature for 12 hours to 5 days to obtain the crystalline form III; or

(2) placing a saturated tetrahydrofuran solution of the compound of formula (A) in a solvent atmosphere of isopropyl ether until the crystalline form III precipitates from the saturated solution.

14. The preparation method of the crystalline form according to claim 2 , wherein the crystalline form IV is prepared by dissolving the compound of formula (A) in n-butanol to give a clear solution, and adding n-heptane under stirring to obtain the crystalline form IV.

15. A composition comprising one or more of the crystalline form I and the crystalline form II wherein a weight ratio of the crystalline form I to the crystalline form II is from 1:99 to 99:1.

16. A pharmaceutical composition comprising a therapeutically effective amount of one, two, or more of the crystalline forms according to claim 2 , and a pharmaceutically acceptable carrier.

17. The crystalline form according to claim 1 , wherein the X-ray powder

diffraction pattern of the crystalline form I further comprises characteristic peaks at diffraction angles (2-Theta) of 13.3±0.2°and 20.1±0.2°,

the X-ray powder diffraction pattern of the crystalline form II further comprises characteristic peaks at diffraction angles (2-Theta) of 7.3±0.2°, 9.6±0.2°, 15.2±0.2°, and 26.3±0.2°,

the X-ray powder diffraction pattern of the crystalline form III further comprises characteristic peaks at diffraction angles (2-Theta) of 12.4±0.2°, and 13.6±0.2°, and

the X-ray powder diffraction pattern of the crystalline form IV further comprises characteristic peaks at diffraction angles (2-Theta) of 8.4±0.2°, 22.6±0.2°, 23.2±0.2°, and 29.7±0.2°.

18. The crystalline form according to claim 17 , wherein the X-ray powder diffraction pattern of the crystalline form I further comprises characteristic peaks at diffraction angles (2-Theta) of 6.3±0.2°, 10.6±0.2°, and 26.3±0.2°;

the X-ray powder diffraction pattern of the crystalline form II further comprises characteristic peaks at diffraction angles (2-Theta) of 11.8±0.2°and 24.6±0.2°,

the X-ray powder diffraction pattern of the crystalline form III further comprises characteristic peaks at diffraction angles (2-Theta) of 19.2±0.2°, and

the X-ray powder diffraction pattern of the crystalline form IV further comprise characteristic peaks at diffraction angles (2-Theta) of 24.0±0.2°.

19. The crystalline form according to claim 18 , wherein the X-ray powder diffraction pattern of the crystalline form I further comprises characteristic peaks at diffraction angles (2-Theta) of 12.7±0.2°,

the X-ray powder diffraction pattern of the crystalline form II further comprises characteristic peaks at diffraction angles (2-Theta) of 22.6±0.2°, and

the X-ray powder diffraction pattern of the crystalline form III further comprises characteristic peaks at diffraction angles (2-Theta) of 10.3±0.2°, 12.2±0.2°, and 21.4±0.2°.

20. The crystalline form of claim 1 , wherein the X-ray powder diffraction pattern of the crystalline form I comprises characteristic peaks at diffraction angles (2-Theta) substantially as shown in FIG. 1 ,

the X-ray powder diffraction pattern of the crystalline form II comprises characteristic peaks at diffraction angles (2-Theta) substantially as shown in FIG. 2 ,

the X-ray powder diffraction pattern of the crystalline form III comprises characteristic peaks at diffraction angles (2-Theta) substantially as shown in FIG. 3 ; and

the X-ray powder diffraction pattern of the crystalline form IV comprises characteristic peaks at diffraction angles (2-Theta) substantially as shown in FIG. 4 .