Nutritional compositions containing phosphatidylethanolamine, sphingomyelin and docosahexaenoic acid
The present disclosure provides a composition and method for promoting functional neuronal development in pediatric subjects. The composition comprises in some embodiments up to about 7 g/100 Kcal of a fat or lipid source; up to about 5 g/100 Kcal of a protein source; about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine; about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin; and about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid. The methods comprise, in some embodiments, administering the aforementioned composition to a pediatric subject.
1. A method for promoting neuronal maturation in a fetus comprising:
administering to a female subject pregnant with the fetus a maternal nutritional supplement comprising:
about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine;
about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin;
about 10 mg/100 Kcal to about 200 mg/100 Kcal of lactoferrin;
about 0.015 g/100 Kcal to about 0.15 g/100 Kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and
about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid.
2. The method of claim 1 , wherein the maternal nutritional supplement further comprises up to about 7 g/100 Kcal of a fat or lipid source; and up to about 5 g/100 Kcal of a protein source.
3. The method of claim 1 , wherein polydextrose and galactooligosaccharide comprise at least about 20% of the prebiotic composition.
4. The method of claim 1 , wherein the maternal nutritional supplement further comprises Lactobacillus rhamnosus GG.
5. The method of claim 1 , wherein the maternal nutritional supplement further comprises arachidonic acid, wherein arachidonic acid and docosahexaenoic acid are present in a weight ratio ranging from about 1:3 to 9:1.
6. The method of claim 1 , wherein the maternal nutritional supplement further comprises human milk oligosaccharides.
7. The method of claim 1 , wherein the phosphatidylethanolamine and sphingomyelin are provided by a milk fat globular membrane-enriched ingredient.
8. The method of claim 1 , wherein the maternal nutritional supplement further comprises a carbohydrate source comprising lactose.
9. A method for promoting neuronal maturation in an infant comprising:
a) administering to a lactating female subject a nutritional supplement comprising:
about 3 mg/100 Kcal to about 50 mg/100 Kcal of phosphatidylethanolamine;
about 0.15 mg/100 Kcal to about 75 mg/100 Kcal of sphingomyelin;
about 10 mg/100 Kcal to about 200 mg/100 Kcal of lactoferrin;
about 0.015 mg/100 Kcal to about 0.15 g/100 Kcal of a prebiotic composition, wherein the prebiotic composition comprises polydextrose, galactooligosaccharide or a combination thereof; and
about 5 mg/100 Kcal to about 75 mg/100 Kcal of docosahexaenoic acid; and
b) administering breast milk from the lactating female to the infant.
10. The method of claim 9 , wherein the nutritional supplement further comprises up to about 7 g/100 Kcal of a fat or lipid source; and up to about 5 g/100 Kcal of a protein source.
11. The method of claim 9 , wherein polydextrose and galactooligosaccharide comprise at least about 20% of the prebiotic composition.
12. The method of claim 9 , wherein the nutritional supplement further comprises Lactobacillus rhamnosus GG.
13. The method of claim 9 , wherein the nutritional supplement further comprises arachidonic acid, wherein arachidonic acid and docosahexaenoic acid are present in a weight ratio ranging from about 1:3 to 9:1.
14. The method of claim 9 , wherein the nutritional supplement further comprises human milk oligosaccharides.
15. The method of claim 9 , wherein the phosphatidylethanolamine and sphingomyelin are provided by a milk fat globular membrane-enriched ingredient.
16. The method of claim 9 , wherein the nutritional supplement further comprises a carbohydrate source comprising lactose.