Liquid preparation comprising pimobendan

1. A method of treatment of a disease or a condition in a subject in a need of such treatment, wherein the subject is a mammal, the method comprising:

administering to the subject in need of such treatment a liquid preparation comprising an etherified cyclodextrin derivative and pimobendan or a pharmaceutically acceptable salt thereof, wherein the etherified cyclodextrin derivative is selected from the group consisting of alpha-, beta, and gamma-cyclodextrin ether;

wherein:

the disease or the condition to be treated is selected from the group consisting of: congestive heart failure (CHF), acute CHF, decompensated endocardiosis (DCE), dilated cardiomyopathy (DCM), asymptomatic (occult) CHF, asymptomatic DCM, shock, gastric dilation, volvulus, myocardial ischemia, and renal ischemia; and

the liquid preparation has a pH of 5.5 to 8.5.

2. The method of claim 1 , wherein the subject is a horse, a dog or a cat.

3. The method of claim 1 , wherein the liquid preparation is administered by injection or infusion.

4. The method of claim 1 , wherein the etherified cyclodextrin derivative comprises hydroxypropyl-beta-cyclodextrin.

5. The method of claim 1 , wherein the etherified cyclodextrin derivative is present in the liquid preparation in an amount of about 15 to 70% (w/v).

6. The method of claim 1 , wherein the etherified cyclodextrin derivative is present in the liquid preparation in an amount of about 20 to 50% (w/v).

7. The method of claim 1 , wherein the etherified cyclodextrin derivative is present in the liquid preparation in an amount of about 20 to 40% (w/v).

8. The method of claim 1 , wherein the liquid preparation has pH value of about 6.5 to 7.5 and an osmolality of about 280 to 300 mOsm/Kg.

9. The method of claim 1 , wherein the preparation comprises about:

a) 20 to 30% (w/v) of a hydroxypropyl-beta-cyclodextrin;

b) 0.005 to 0.15% (w/v) pimobendan or a pharmaceutical acceptable salt thereof;

and wherein the pH of the liquid is adjusted to about 6.5 to 7.5 and the osmolality is about 280 to 300 mOsm/Kg.

10. The method of claim 1 , wherein the liquid preparation is administered to the subject in a daily dosage amount that provides about 0.05 to 0.5 mg pimobendan per kg body weight of the subject.

11. The method of claim 1 , wherein the liquid preparation is administered to the subject in a daily dosage amount that provides about 0.1 to 0.3 mg pimobendan per kg body weight of the subject.

12. The method of claim 1 , wherein the liquid preparation is administered to the subject in a daily dosage amount that provides about 0.15 mg pimobendan per kg body weight of the subject.

13. The method of claim 1 , wherein pimobendan is provided in the liquid formulation in a concentration of about 0.75 mg/ml.