Systems and methods for calculating patient dosage
Systems and methods for providing a dosage on a device comprising an electronic circuit, an input device, and a display screen. The method includes receiving an input signal of a user indicating an input directed to a patient sex and patient status selected from the group comprising new patient, returning patient and booster patient. If the patient sex is female, an effective estradiol dosage and an effective testosterone dosage are determined using dosage calculation methods selected based on the patient status and additional female input parameters. If the patient sex is male an effective testosterone dosage is determined using dosage calculation methods selected based on the patient status and additional male input parameters.
1. A method of treating a patient with hormone replacement therapy,
the method comprising:
receiving, by a user interface of a computerized device, an input indicating a patient gender and transmitting the patient gender input to a processor of the computerized device;
receiving, by the processor, a current level of testosterone for the patient;
receiving, by the processor, a current level of estradiol treatment for the patient;
assigning, by the processor, a male testosterone dosage in response to receiving a patient gender input that is male using a process comprising:
receiving, by the processor, an input indicating a patient weight;
accessing, by the processor, a lookup table comprising a base testosterone dosage and determining, by the processor, the base testosterone dosage based on the patient weight;
determining, by the processor, a first intermediate testosterone dosage by multiplying the base testosterone dosage by a male age factor;
determining, by the processor, a second intermediate testosterone dosage by multiplying the first intermediate testosterone dosage by a male adjustment factor based on a received input of a patient history of prostate cancer or benign prostatic hyperplasia (BPH;
determining, by the processor, the male testosterone treatment dosage by adding a male increment based on a received input of a level of physical activity;
if the current level of testosterone is below 700 mg, assigning the male testosterone dosage to the male patient; and
administering the assigned male testosterone dosage to the male patient; and
assigning, by the processor, an estradiol dosage in response to receiving a patient gender input that is female using a process comprising:
receiving, by the processor, an input comprising a patient weight and an input comprising a patient age;
receiving, by the processor, a current level of follicle stimulating hormone (FSH) for the patient;
accessing, by the processor, a first lookup table comprising a first base estradiol dosage and determining, by the processor, the first base estroidiol dosage based on a ratio of the patient weight to the patient age;
accessing, by the processor, a second lookup table comprising a second base estradiol dosage and determining, by the processor, the second base estradiol dosage based on the patient age;
accessing, by the processor, a third lookup table comprising a third base estradiol dosage and determining, by the processor, the third base estradiol dosage based on a received input of the current level of follicle stimulating hormone (FSH) of the patient;
determining, by the processor, a first intermediate estradiol dosage by summing the first, second, and third base estradiol dosages;
determining, by the processor, a second intermediate estradiol dosage by multiplying the first intermediate estradiol dosage by a problem factor;
determining, by the processor, the estradiol dosage by adding an FSH adjustment to the second intermediate estradiol dosage; and
assigning, by the processor, the estradiol dosage if the patient is not premenopausal; and
assigning, by the processor, a testosterone dosage in response to receiving a patient gender input that is female using a process comprising:
accessing, by the processor, a fourth lookup table comprising a first base testosterone dosage and determining, by the processor, a first base testosterone dosage based on the patient weight;
accessing, by the processor, a fifth lookup table comprising a second base testosterone dosage and determining, by the processor, a second base testosterone dosage based on a received input of a current level of testosterone of the patient;
determining, by the processor, the female testosterone dosage by summing the first and second base testosterone dosages and multiplying by a female age factor;
assigning, by the processor, the female testosterone dosage to the female patient; and
administering at least one of the female estradiol dosage and the female testosterone dosage to the female patient.
2. The method of claim 1 , wherein the base testosterone dosage is based on weight according to the following table:
Weight (lbs.)
Value (mg)
<151
1200
151-175
1400
176-200
1600
201-225
1800
226-250
2000
251-275
2200
276-300
2400
301-350
2600
351-400
2800
>400
3000.
3. The method of claim 2 , wherein the male adjustment factor is 0.95 if the patient has a history of BPH, 0.90 if the patient has a history of prostate cancer, and 0.90 if the patient has a history of both BPH and prostate cancer.
4. The method of claim 3 , wherein the male increment is −100 mg if the patient is sedentary, +100 mg if the patient exercises 5 times/week, receives a weekly testosterone injection, or uses a testosterone gel.
5. The method of claim 1 , wherein the first base estradiol dosage is based on a ratio of weight to age according to the following table:
Weight/Age Ratio (lbs/Years)
Value (mg)
0-1.5
1
1.6-2.5
2
2.6-3.9
3
>4
2.
6. The method of claim 5 , wherein the second base estradiol dosage is based on age according to the following table:
Age (Years)
Value
<40
3
40-50
5
51-60
15
61-68
12.5
>68
4.
7. The method of claim 6 , wherein the third base estradiol dosage is based on the current level of FSH according to the following table:
FSH
Value
<31
0
31-50
1
51-100
2
>100
3.
8. The method of claim 7 , wherein the problem factor is 0.90 if the patient has a history of acne or facial hair, 0.88 if the patient has a history of hair loss or heavy menses or has had a hysterectomy, 0.80 if the patient has a history of persistent breast pain or mid-cycle bleeding, 0.75 if the patient has a history of PCOS, headache, or fluid retention, and 0.70 if the patient has a history of fibrocystic breast disease.
9. The method of claim 8 , wherein the FSH adjustment factor is 12.5 if the patient is between 20 and 50 years of age and the FSH is 30 or more.
10. The method of claim 1 , wherein the first base testosterone dosage is based on weight according to the following table:
Weight (lbs)
Value (mg)
75-150
75
151-200
87.5
>200
100.
11. The method of claim 10 , wherein the female age factor is based on age according to the following table:
Age (Years)
Value
0-67
1
>67
0.63.
12. A method of treating a patient with hormone replacement therapy, comprising:
receiving, by a processor of a computerized device, an input of a current level of testosterone for a hormone replacement therapy patient;
receiving, by the processor, an input of a current level of testosterone treatment for the patient;
receiving, by the processor, an input of a current level of estradiol treatment for the patient;
if the patient is male, assigning a male testosterone dosage by a process comprising:
determining, by the processor, a base testosterone dosage based on a received input of a weight of the patient;
receiving, by the processor an input of an age of the patient;
determining, by the processor, a first intermediate testosterone dosage by multiplying the base testosterone dosage by 0.80 if the patient is above 68 years of age;
determining, by the processor, a second intermediate testosterone dosage by multiplying the first intermediate testosterone dosage by a male adjustment factor based on history of prostate cancer or benign prostatic hyperplasia (BPH;
determining, by the processor, the male testosterone dosage by adding a male increment based on level of physical activity;
assigning, by the processor, the male testosterone dosage; and
administering the assigned male testosterone dosage to the male patient;
if the patient is female, assigning an estradiol dosage by a process comprising:
receiving, by the processor, an input of a current level of follicle stimulating hormone (FSH), a weight, and an age for the patient;
determining, by the processor, a first base estradiol dosage based on a ratio of weight to age;
determining, by the processor, a second base estradiol dosage based on the age of the patient according to the following table:
Age (Years)
Value
<40
3
40-50
5
51-60
15
61-68
12.5
>68
4;
determining, by the processor, a third base estradiol dosage based on the current level of FSH;
determining, by the processor, a first intermediate estradiol dosage by summing the first, second, and third base estradiol dosages;
determining, by the processor, a second intermediate estradiol dosage by multiplying the first intermediate estradiol dosage by a problem factor;
determining, by the processor, the estradiol dosage by adding an FSH adjustment to the second intermediate estradiol dosage; and
assigning, by the processor, the estradiol dosage if the patient is not premenopausal;
and
if the patient is female, assigning a female testosterone dosage by a process comprising:
determining, by the processor, a first base testosterone dosage based on weight;
determining, by the processor, a second base testosterone dosage based on a received input of a current level of testosterone;
determining, by the processor, the female testosterone dosage by summing the first and second base testosterone dosages and multiplying by a female age factor;
assigning the female testosterone dosage; and
administering at least one of the assigned female estradiol dosage and assigned female testosterone dosage to the female patient.
13. The method of claim 12 , wherein the base testosterone dosage is based on weight according to the following table:
Weight (lbs.)
Value (mg)
<151
1200
151-175
1400
176-200
1600
201-225
1800
226-250
2000
251-275
2200
276-300
2400
301-350
2600
351-400
2800
>400
3000.
14. The method of claim 13 , wherein the male adjustment factor is 0.95 if the patient has a history of BPH, 0.90 if the patient has a history of prostate cancer, and 0.90 if the patient has a history of both BPH and prostate cancer.
15. The method of claim 14 , wherein the male increment is −100 mg if the patient is sedentary, +100 mg if the patient exercises 5 times/week, receives a weekly testosterone injection, or uses a testosterone gel.
16. The method of claim 12 , wherein the first base estradiol dosage is based on a ratio of weight to age according to the following table:
Weight/Age Ratio (lbs/Years)
Value (mg)
0-1.5
1
1.6-2.5
2
2.6-3.9
3
>4
2.
17. The method of claim 16 , wherein the third base estradiol dosage is based on the current level of FSH according to the following table:
FSH
Value
<31
0
31-50
1
51-100
2
>100
3.
18. The method of claim 17 , wherein the problem factor is 0.90 if the patient has a history of acne or facial hair, 0.88 if the patient has a history of hair loss or heavy menses or has had a hysterectomy, 0.80 if the patient has a history of persistent breast pain or mid-cycle bleeding, 0.75 if the patient has a history of PCOS, headache, or fluid retention, and 0.70 if the patient has a history of fibrocystic breast disease.
19. The method of claim 18 , wherein the FSH adjustment factor is 12.5 if the patient is between 20 and 50 years of age and the FSH is 30 or more.
20. The method of claim 12 , wherein the first base testosterone dosage is based on weight according to the following table:
Weight (lbs)
Value (mg)
75-150
75
151-200
87.5
>200
100.