Cyclic prosaposin peptides and uses thereof
Provided herein are cyclic prosaposin peptides and compositions and uses thereof. Exemplary uses include use in the treatment of cancer or in the treatment of inflammatory diseases or disorders.
1. A peptide consisting of the amino acid sequence DWGPK (SEQ ID NO: 2) or dWGPK (SEQ ID NO: 4), wherein the peptide is cyclic.
2. The peptide of claim 1 , further comprising one or more modifications selected from the group consisting of pegylation, glycosylation, acetylation, amidation, and phosphorylation.
3. The peptide of claim 1 , wherein the peptide is linked to a polymer that enhances the serum half-life.
4. The peptide of claim 3 , wherein the polymer is selected from the group consisting of polyvinyl pyrrolidone, polyvinyl alcohol, divinylether maleic anhydride, N-(2-hydroxypropyl)-methacrylamide, dextran, dextran sulfate, polypropylene glycol, polyoxyethylated polyol, heparin, heparin fragments, polysaccharides, cellulose, methylcellulose, carboxymethyl cellulose, starch, polyalkylene glycol and derivatives thereof, copolymers of polyalkylene glycols and derivatives thereof, polyvinyl ethyl ethers, and α,β-Poly(2-hydroxyethyl)-DL-aspartamide.