Microneedle, mould for producing same, and production method for same
The present invention relates to a microneedle, to a mould for producing same, and to a production method for same. More specifically, the present invention concerns a microneedle for causing a skin-beautifying substance or drug to be absorbed via the skin, to a plastic mould for producing same, and to a production method for same.
1. A micro-needle composition for percutaneous delivery of a dermal cosmetic material or drug, the composition comprising:
a plurality of micro-needles; and
a non-aqueous media comprising the dermal cosmetic material or drug,
wherein the plurality of microneedles comprises a tetrahedral or pyramidal body with four or five pointed vertices that are not fixed to a flat base or substrate,
wherein the plurality of micro-needles are water-dissolvable and mixed with the non-aqueous media such that the tetrahedral or pyramidal body is randomly oriented in the composition,
wherein, when pressed against skin, any of the four or five pointed vertices of the randomly oriented the tetrahedral or pyramidal body is configured to pierce stratum corneum of the skin for facilitating the dermal cosmetic material or drug to diffuse into dermis underneath the stratum corneum.
2. The micro-needle composition of claim 1 , wherein the tetrahedral or pyramidal body is made of a water-dissolvable, biocompatible material selected from the group consisting of a polysaccharide, a polyvinyl alcohol, a carboxyvinyl polymer, chitosan, hyaluronic acid, a cellulose polymer, and NaCl salt.
3. The micro-needle composition of claim 1 , wherein the tetrahedral or pyramidal body has a length of 50 μm to 500 μm.
4. The micro-needle composition of claim 1 , wherein the tetrahedral or pyramidal body is soluble in body fluid.
5. The micro-needle composition of claim 1 , wherein the dermal cosmetic material is selected from the group consisting of an antioxidant, a growth factor, an anti-wrinkle agent, a cell culture, and a culture medium.
6. The micro-needle composition of claim 5 , wherein the antioxidant is vitamin C.
7. The micro-needle composition of claim 5 , wherein the growth factor is selected from the group consisting of epithelial growth factor (EGF) and fibroblast growth factor (FGF).
8. The micro-needle composition of claim 5 , wherein the cell culture is a stem cell culture, and wherein the culture medium is a stem cell culture medium.
9. The micro-needle composition of claim 7 , wherein the drug is selected from the group consisting of a vaccine, insulin, and a growth hormone.